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Publikováno v:
Journal of Cellular Physiology. 237:1245-1265
The main manifestation of obesity is persistent low-level inflammation and insulin resistance, which is an important factor inducing or promoting other obesity-related diseases. As a proinflammatory programmed cell death, pyroptosis plays an importan
Publikováno v:
Journal of Cellular Biochemistry
As per the World Health Organization report, around 226 844 344 confirmed positive cases and 4 666 334 deaths are reported till September 17, 2021 due to the recent viral outbreak. A novel coronavirus (severe acute respiratory syndrome coronavirus 2
Autor:
Ellis J. Neufeld, Nickhill Bhakta, Nancy S. Bolous, Andrew M. Davidoff, Ulrike M. Reiss, Huiqi Wang, Carlos Rodriguez-Galindo, Amit C. Nathwani, Meenakshi Devidas, Michael M Meagher, Bryan A. Piras, Timothy W. Jacobs, Yichen Chen
Publikováno v:
Blood. 138:1677-1690
Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce morbidity associated with hemophilia. Although multiple clinical trials continue to evaluate efficacy and safety, limited cost-effectiveness data have been pu
Autor:
Thorsten Stühmer, Cornelia Vogt, Manik Chatterjee, Rafael Alonso Fernández, José I. Martín-Subero, K. Martin Kortüm, Peter Raab, Seungbin Han, Larissa Haertle, Yanira Ruiz-Heredia, Umair Munawar, Jan Krönke, Miriam Kull, Leo Rasche, Xiang Zhou, Hermann Einsele, Xabier Agirre, Niccolo Bolli, Anna Ruckdeschel, Josip Zovko, Joaquin Martinez-Lopez, Andoni Garitano-Trojaola, Matteo Claudio Da Via, Max Bittrich, Thomas Haaf, Santiago Barrio
Publikováno v:
Blood
Cereblon is the direct binding target of the immunomodulatory drugs (IMiDs) that are commonly used to treat multiple myeloma (MM), the second most frequent hematologic malignancy. Patients respond well to initial treatment with IMiDs, but virtually a
Autor:
P. Andrew Futreal, Ken Furudate, Marina Konopleva, Sanam Loghavi, Guillermo Garcia-Manero, Sa A. Wang, Yuya Sasaki, Gheath Alatrash, Musa Yilmaz, Koji Sasaki, Naveen Pemmaraju, Latasha Little, Tapan M. Kadia, Koichi Takahashi, Farhad Ravandi, Kiyomi Morita, Curtis Gumbs, Jairo Matthews, Feng Wang, Hagop M. Kantarjian, Courtney D. DiNardo, Richard E. Champlin, Naval Daver, Tomoyuki Tanaka
Publikováno v:
Blood
Introduction While clonal hematopoiesis (CH) can precede the development of AML, preleukemic CH can persist after attaining remission. In rare cases, non-leukemic CH can also emerge after remission. Long-term clonal dynamics of persistent CH or emerg
Autor:
Philomena Colucci, Jingbo Yu, Jonathan Kish, Dilan Paranagama, Shreekant Parasuraman, Kevin C Lord, Ivy Altomare
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e915-e921
Background Polycythemia vera (PV) is a myeloproliferative neoplasm affecting >100,000 people in the United States annually. Patients (pts) with PV are at risk for thromboembolic events (TEs), premature death, and high symptom burden. Hydroxyurea (HU)
Publikováno v:
Biochemical and Biophysical Research Communications. 577:158-164
Sorafenib is a tyrosine kinase inhibitor that shows anti-tumour effects against various cancers including gastric cancer (GC). However, the clinical application of sorafenib is often hampered by drug resistance. Sirtuins 6 (SIRT6) is a member of the
Publikováno v:
Biochemical Society Transactions
Pyroptosis is a highly inflammatory and lytic type of programmed cell death (PCD) commenced by inflammasomes, which sense perturbations in the cytosolic environment. Recently, several ground-breaking studies have linked a family of pore-forming prote
Autor:
Pithi Chanvorachote, Preedakorn Chunhacha, Maneewan Suksomtip, Zin Zin Ei, Chanida Vinayanuwattikun, Alisa Tubsuwan, Decha Pinkaew, Kanuengnit Choochuay
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly
Autor:
Gabrielle Walsh, Wenshuo Zhou, Alexei Medvedev, Barbara K. Felber, Sanjai Kumar, Jasper Perry-Anderson, Victoria Majam, Konstantin Virnik, Ira Berkower
Publikováno v:
Biochem Biophys Res Commun
There is an urgent need for a malaria vaccine that can prevent severe disease in young children and adults. Despite earlier work showing an immunological mechanism for preventing infection and reducing disease severity, there is currently no reliable