Zobrazeno 11 - 20
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Autor:
Monique Verhaegen, Arul M. Chinnaiyan, Julia VanGoor, Drew Pratt, Doris Mangelberger, Xuhong Cao, Fengyun Su, Andrzej A. Dlugosz, Jean C. Tien, Josh N. Vo, Jae Eun Choi, Paul W. Harms, Vincent T. Ma, Saravana M. Dhanasekaran
Publikováno v:
J Invest Dermatol
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that is classified as Merkel cell polyomavirus (MCPyV)-positive or virus-negative. Epigenetic changes, such as DNA methylation, can alter gene expression and influence ca
Publikováno v:
Antioxid Redox Signal
SIGNIFICANCE: Metformin has been proposed as a treatment for systemic lupus erythematosus (SLE). The primary target of metformin, the electron transport chain complex I in the mitochondria, is associated with redox homeostasis in immune cells, which
Autor:
Julio C. Chavez, James Drew, John P. Leonard, Erin Mulvey, Sonali M. Smith, Leandro Cerchietti, Nancy L. Bartlett, John L. Reagan, Jeffrey A. Jones, Ann S. LaCasce, Peter Martin, Maria Victoria Revuelta, Chengqing Wu
Publikováno v:
Blood. 139:1147-1159
Resistance to standard immunochemotherapy remains an unmet challenge in diffuse large B-cell lymphoma (DLBCL), and aberrant DNA methylation may contribute to chemoresistance. Promising early-phase results were reported with rituximab, cyclophosphamid
Autor:
Jonathan C. Roberts, Keith R. McCrae, Habiba Hussain, Michael D. Tarantino, Shruti Chaturvedi
Publikováno v:
Blood Advances. 6:1271-1277
Introduction:Antiphospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis in the presence of antiphospholipid antibodies. Recently, derangement in the complement pathway has been implicated in APS pathophysiology. Refractory
Publikováno v:
Molecular and Cellular Biochemistry. 477:1329-1338
Inflammation contributes to the pathogenesis of liver disease, and inflammasome activation has been identified as a major contributor to the amplification of liver inflammation. Transforming growth factor-beta (TGF-β) is a key regulator of liver phy
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Autor:
Xiao-Li Zheng, Hengxiang Wang, Ning Mao, Dong-Mei Han, Heng Zhu, Hong-Min Yan, Zi-Kuan Guo, Mei Xue, Ling Zhu, Jing Liu, Hong-Mei Ning, Li Ding
Publikováno v:
Cytotherapy. 24:205-212
Background aims Despite the great advances in immunosuppressive therapy for severe aplastic anemia (SAA), most patients are not completely cured. Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) has been recommended as an alternati
Publikováno v:
Bioengineered, Vol 13, Iss 2, Pp 3620-3633 (2022)
Preeclampsia (PE) is a pregnancy disorder characterized by excessive trophoblast cell death. This study aims to explore the exact mechanism of the ubiquitination level of FUN14 domain containing 1 (FUNDC1) in mitophagy and injury in hypoxic trophobla
Autor:
Aleksandra Danielak, Jerzy Hankus, John L. Wallace, Marcin Magierowski, Malgorzata Szetela, Urszula Głowacka, Anna Chmura, Jakub Cieszkowski, Katarzyna Magierowska, Edyta Korbut, Dagmara Wojcik, Marcin Surmiak
Publikováno v:
Antioxidants & Redox Signaling. 36:189-210
Aims: Nonsteroidal anti-inflammatory drugs, including ketoprofen, induce adverse effects within the gastrointestinal (GI)-tract. Hydrogen sulfide (H2S) is an antioxidative gaseous mediator contribu...
Autor:
Hongseok Yun, Seung Hong Choi, Ka Young Lim, Seung-Ki Kim, Yumi Shim, Tae Min Kim, Jin-Woo Park, Hyunhee Kim, Jeongwan Kang, Sung Hye Park, Chul-Kee Park, Kwanghoon Lee, Jae Kyung Won
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Mismatch repair-deficient (MMRD) brain tumors are rare among primary brain tumors and can be induced by germline or sporadic mutations. Here, we report 13 MMRD-associated (9 sporadic and 4 Lynch syndrome) primary brain tumors to determine clinicopath