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Autor:
Atsuko Shono, Coenraad K van Kalken, Peter J. van der Spek, Eric P Krenning, Toru Kotani, Djo Hasan
Publikováno v:
Purinergic Signalling
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm. Therefore, COVID-19 patients are treated with
Autor:
Stephen S. Rich, Donna Neuberg, Michael H. Cho, Bing Yu, Matthew Leventhal, George T. O'Connor, Ani Manichaikul, Weiwei Shi, Lynette M. Sholl, Michael C. Honigberg, Abhishek Niroula, Benjamin L. Ebert, Joselyn Rojas-Quintero, R. Graham Barr, Matthew Moll, Stephanie J. London, L. Adrienne Cupples, Siddhartha Jaiswal, Elizabeth C. Oelsner, Brittany E Sandoval, Pradeep Natarajan, Brian E. Cade, Peter van Galen, Susan Redline, Yohannes Tesfaigzi, Christopher J. Gibson, Stephanie M. Gogarten, COPDGene Study Investigators, Deepti Jain, Adolfo Correa, Bruce D. Levy, Sina A. Gharib, Peter Miller, Kaushik Viswanathan, Caroline A. Owen, Edwin K. Silverman, Lillian Werner, Jerome I. Rotter, Dandi Qiao, Brian C. Miller, Adam S. Sperling, Leslie A. Lange, Alexander G. Bick, Marie McConkey, Vasan S. Ramachandran
Publikováno v:
Blood. 139:357-368
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic
Autor:
Anna-Maria Fink, Tobias Gaska, Barbara Eichhorst, Werner Freier, Clemens-Martin Wendtner, Can Zhang, Julia von Tresckow, Kirsten Fischer, Ursula Vehling-Kaiser, Eugen Tausch, Stephan Stilgenbauer, Marcel Reiser, Martina Stauch, Michael J. Eckart, Sandra Robrecht, Petra Langerbeins, Moritz Fürstenau, Paula Cramer, Rudolf Schlag, Lothar Müller, Karl-Anton Kreuzer, Michael Hallek, Christina Balser, Othman Al-Sawaf
Publikováno v:
Blood. 139:177-187
Observation is the current standard of care for patients with early-stage asymptomatic chronic lymphocytic leukemia (CLL), as chemotherapy-based interventions have failed to prolong survival. We hypothesized that early intervention with ibrutinib wou
Publikováno v:
Aging (Albany NY)
Background Diabetic nephropathy is a major complication of diabetes. We explore the protective effect of TRPM2 knockdown on the progression of diabetic nephropathy. Methods A type 2 diabetes animal model was established in C57BL/6N mice by long-term
Autor:
Austyn Colter, James Ropa, Melissa L. Fishel, Brian Parkin, Maegan L. Capitano, Heiko Konig, George E. Sandusky, Claudiu T. Supuran, Callista Maguire, Fangli Chen, Daniela N. Petrusca, Max Jacobsen, Xue Wu, H. Scott Boswell, Emilia Licarete, Fabrizio Carta, Magdalena Czader
Publikováno v:
Journal of Cellular and Molecular Medicine
Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and survive in specialised, oxygen (
Autor:
Philomena Colucci, Jingbo Yu, Jonathan Kish, Dilan Paranagama, Shreekant Parasuraman, Kevin C Lord, Ivy Altomare
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e915-e921
Background Polycythemia vera (PV) is a myeloproliferative neoplasm affecting >100,000 people in the United States annually. Patients (pts) with PV are at risk for thromboembolic events (TEs), premature death, and high symptom burden. Hydroxyurea (HU)
Autor:
Khadidiatou Guiro, Lauren S. Sherman, Marina Gergues, Oleta A. Sandiford, Michael J. Schonning, Pranela Rameshwar, Robert J. Donnelly, Garima Sinha, Sri Harika Pamarthi, Seda Ayer, Steven J. Greco, Jean-Pierre Etchegaray, Markos H. El-Far, Yannick Kenfack
Publikováno v:
Aging (Albany NY)
This study addresses the potential to reverse age-associated morbidity by establishing methods to restore the aged hematopoietic system. Parabiotic animal models indicated that young secretome could restore aged tissues, leading us to establish a het
Publikováno v:
Aging (Albany NY)
Fibroblast-like synoviocytes (FLS) obtained from the joint synovium of rheumatoid arthritis (RA) patients exhibit hyperplasia and aggressive inflammatory phenotypes. This study was designed to explore the anti-inflammatory mechanism of IL-6R inhibito
Autor:
Marija Petrusevska, Dragica Zendelovska, Nikola Labachevski, Emilija Atanasovska, Katerina Spasovska, Katerina Kasapinova, Kalina Gjorgjievska, Milena Stevanovikj
Publikováno v:
Redox Report : Communications in Free Radical Research
article-version (VoR) Version of Record
Redox Report, Vol 26, Iss 1, Pp 184-189 (2021)
article-version (VoR) Version of Record
Redox Report, Vol 26, Iss 1, Pp 184-189 (2021)
BACKGROUND: COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels,
Autor:
Michael Z. Zulu, Ilhem Messaoudi, James D. Brien, Alexandria Dickson, Neil Tedeschi, Richard H. Scheuermann, Tara L. Steffen, Delia F. Tifrea, Kevin J. Maroney, Sarah L. George, Amelia K. Pinto, Yun Zhang, Amanda N. Pinski
Publikováno v:
Journal of Leukocyte Biology
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of coronavirus disease‐2019 (COVID‐19), a respiratory disease that varies in severity from mild to severe/fatal. Several risk factors for severe disease have