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Autor:
Shijian Xiang, Ronghua Yang, Ning Gu, Xiaobing Pi, Bo Liang, Jiehua Li, Kai Yu, Sitong Zhou, Xiaodong Chen
Publikováno v:
Journal of Cellular and Molecular Medicine
Skin cutaneous melanoma (SKCM) is one of the most destructive skin malignancies and has attracted worldwide attention. However, there is a lack of prognostic biomarkers, especially tumour microenvironment (TME)‐based prognostic biomarkers. Therefor
Publikováno v:
Journal of Cellular and Molecular Medicine
This study aimed to explore the possibility of miR‐423‐5p modified adipose‐derived stem cell (ADSCs) therapy on streptozotocin (STZ)‐induced diabetes mellitus erectile dysfunction (DMED) rats. MiR‐423‐5p was knocked down in ADSCs. ADSCs,
Autor:
Chih-Chao Yang, John Y. Chiang, Yi-Chen Li, Pei-Hsun Sung, Hon-Kan Yip, Mel S. Lee, Kuan-Hung Chen, Tien-Hung Huang
Publikováno v:
Journal of Cellular and Molecular Medicine
This study tested the hypothesis that therapy with double overexpression of miR‐19a‐3p and miR‐20a‐5p (miRDOE) to human inducible pluripotent stem cell–derived mesenchymal stem cells (iPS‐MSCs) was superior to iPS‐MSCs alone for preserv
Publikováno v:
Journal of Cellular and Molecular Medicine
Lipotoxicity has been shown to cause dysfunction of many organs and tissues. However, it is unclear whether lipotoxicity is harmful to the somatotrophs, a kind of cell that synthesize growth hormone (GH) in the pituitary. In this study, we performed
Autor:
Wu Zhang, Qi Ling, Shi Feng, Qinfen Xie, Haitao Huang, Lingjian Wang, Qian Wang, Ming Yao, Ruihan Chen, X. Zhang, Aodi Wang, Shuirong Zhang
Publikováno v:
Journal of Cellular and Molecular Medicine
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers, can be divided into head and body/tail cancers anatomically. We previously reported a prognostic relevance of tumour location in resectable PDAC. This study aimed to furth
Autor:
Meng Zhao, Yanrong Lu, Tiantian Wei, Ling Li, Liang Ma, Ping Fu, Shuyun Liu, Jingping Liu, Yanhuan Feng, Chengshi Wang
Publikováno v:
Journal of Cellular and Molecular Medicine
Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐regulation and gut dysbiosis are found in T2DM, their roles in DKD are unclear. Here, we investigated the effect of C5 on the gut microbiota during DKD development. R
Autor:
Zequn Li, Xingxin Zhu, Shiyu Zhang, Zefeng Xuan, Guangyuan Song, Wenfeng Song, Shusen Zheng, Haiyang Xie, Penghong Song, Long Zhao
Publikováno v:
Journal of Cellular and Molecular Medicine
The farnesoid X receptor (FXR), as a bile acid (BA) sensor, plays an important role in the regulation of lipid metabolism. However, the effects and underlying molecular mechanisms of FXR on intestinal glucose homeostasis remain elusive. Herein, we de
Publikováno v:
Journal of Cellular and Molecular Medicine
Current studies have shown that long non‐coding RNAs (lncRNAs) may serve as prognostic biomarkers in multiple cancers. Therefore, we postulated that expression patterns of multiple lncRNAs combined into a single signature could improve clinicopatho
Publikováno v:
Journal of Cellular and Molecular Medicine
Gastric cancer (GC) is the sixth most common malignancy and the third leading cause of cancer‐related death worldwide. Emerging evidence suggests that tumour microenvironment cells play a vital role in the development and prognosis of GC. To invest
Publikováno v:
Journal of Cellular and Molecular Medicine
Ovarian cancer (OV) is one of the leading causes of cancer deaths in women worldwide. Late diagnosis and heterogeneous treatment result to poor survival outcomes for patients with OV. Therefore, we aimed to develop novel biomarkers for prognosis pred