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Autor:
Lucie Kolářová, Maya Shemesh, Yoav Peleg, Pavel Mikulecký, Maroš Huličiak, Gideon Schreiber, Bohdan Schneider, Jiří Zahradník
Publikováno v:
The FEBS Journal. 289:2672-2684
We hereby describe the process of design and selection of non-antibody protein binders mimicking cytokine signaling. We chose to mimic signaling of IFN-λ1, type 3 interferon (also known as IL-29) for its novelty and the importance of its biological
Autor:
Chen Wang, Rugang Zhang, Ronny Drapkin, Benjamin G. Bitler, Dajiang Guo, Jianhuang Lin, Heng Liu, Iris Müller, Wei Zhou, Andrew V. Kossenkov, Kristian Helin
Publikováno v:
Cancer Immunol Res
The tumor immune microenvironment is influenced by the epigenetic landscape of the tumor. Here, we have identified the SETDB1–TRIM28 complex as a critical suppressor of antitumor immunity. An epigenetic CRISPR–Cas9 screen of 1,218 chromatin regul
Autor:
Fan-Hua Nan, Po-Tsang Lee, Hong-Yi Gong, Meng-Chou Lee, Yu-Lin Lin, Jiun-Yan Loh, Ho Thi Hang, Ming-Wei Lu, Nguyen Bao Trung
Publikováno v:
Fish & Shellfish Immunology. 119:587-601
Toll-like receptors (TLRs) are evolutionarily conserved proteins of pattern recognition receptors (PRRs) and play a crucial role in innate immune systems recognition of conserved pathogen-related molecular samples (PAMPs). We identified and character
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 968-980 (2021)
Virulence
article-version (VoR) Version of Record
Virulence
article-version (VoR) Version of Record
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
Autor:
Wenqing Ma, Yong Zhao, Yu-wei Gao, Xingyu Li, Wenqi Wang, Hongbin He, Yudong Zhao, Tiecheng Wang, Xiaomei Ma, Xuefeng Wang, Chunqing Xu, Xue Wang, Song Jin, Peili Hou, Hongmei Wang, Zhangping Yu, Huasong Chang
Publikováno v:
Cellular and Molecular Immunology
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and mortality in humans. It is urgent to understand the function of viral genes. However, the f
Publikováno v:
Mediators of Inflammation
Mediators of Inflammation, Vol 2021 (2021)
Mediators of Inflammation, Vol 2021 (2021)
Endothelial inflammation is a crucial event in the initiation of atherosclerosis. Here, we identify Ataxin-10 protein as a novel negative modulator of endothelial activation by suppressing IRF-1 transcription activity. The protein level of Ataxin-10
Publikováno v:
Journal of Cellular and Molecular Medicine
The aim of this study is to identify potential biomarker of tuberculosis (TB) and determine its function. Differentially expressed mRNAs(DEGs) were selected from a blood database GSE101805, and then, 30 key genes were screened using STING, Cytoscape
Publikováno v:
Biochemical Journal. 478:3905-3921
We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic analysis that α
Autor:
Yujin Shi, Wensheng Wei, Tao Jiao, Tian Zheng, Ruiyi Ma, Lili Ren, Qi Jiang, Zichun Xiang, Zhixun Dou, Jian Rao, Zhuo Zhou, Xinyi Zhang, Zhengfan Jiang, Jianwei Wang, Wenjing Wang, Xia Xiao, Tao Deng, Xiaojing Dong, Xiaobo Lei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the host immune system senses and responds to SARS-CoV-2 infection remain to be determi
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1