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Publikováno v:
Blood. 139:2130-2144
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulatin
Autor:
Pooria Fallah, Huling Lyu, Dan Burch, Deborah Foyle, Thomas G.H. Diekwisch, Xianghong Luan, Xiaofeng Zhou, Mirali Pandya
Publikováno v:
Semin Cell Dev Biol
Periodontal disease is an inflammatory reaction of the periodontal tissues to oral pathogens. In the present review we discuss the intricate effects of a regulatory network of gene expression modulators, microRNAs (miRNAs), as they affect periodontal
Autor:
Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez, Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, Langerak, Anton W, IRAS OH Epidemiology Chemical Agents
Publikováno v:
Blood, 139(10), 1557-1563. American Society of Hematology
Blood, 139(10). American Society of Hematology
Blood, 139(10). American Society of Hematology
Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely
Publikováno v:
Journal of Investigative Dermatology. 142:774-780
Regulatory T cells (Tregs) play a critical role in regulating tissue inflammation. Reduced Treg numbers and/or suppressive function contribute to autoimmune disease. Tregs can adopt the transcriptional programming of T helper (Th) type-1/2/17 cells t
Autor:
Atsuko Shono, Coenraad K van Kalken, Peter J. van der Spek, Eric P Krenning, Toru Kotani, Djo Hasan
Publikováno v:
Purinergic Signalling
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm. Therefore, COVID-19 patients are treated with
Autor:
O. Nalcaci, Hanns-Rudolf Paur, Silvia Diabaté, Clarissa Marquardt, Henning Bockhorn, Carsten Weiss, A. Panas, Sonja Mülhopt, Werner Baumann
In cell culture studies, foetal calf serum (FCS) comprising numerous different proteins is added, which might coat the surface of engineered nanomaterials (ENMs) and thus could profoundly alter their biological activities. In this study, a panel of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ac3b005a3bed1de912acd448b43311
Autor:
Stephen S. Rich, Donna Neuberg, Michael H. Cho, Bing Yu, Matthew Leventhal, George T. O'Connor, Ani Manichaikul, Weiwei Shi, Lynette M. Sholl, Michael C. Honigberg, Abhishek Niroula, Benjamin L. Ebert, Joselyn Rojas-Quintero, R. Graham Barr, Matthew Moll, Stephanie J. London, L. Adrienne Cupples, Siddhartha Jaiswal, Elizabeth C. Oelsner, Brittany E Sandoval, Pradeep Natarajan, Brian E. Cade, Peter van Galen, Susan Redline, Yohannes Tesfaigzi, Christopher J. Gibson, Stephanie M. Gogarten, COPDGene Study Investigators, Deepti Jain, Adolfo Correa, Bruce D. Levy, Sina A. Gharib, Peter Miller, Kaushik Viswanathan, Caroline A. Owen, Edwin K. Silverman, Lillian Werner, Jerome I. Rotter, Dandi Qiao, Brian C. Miller, Adam S. Sperling, Leslie A. Lange, Alexander G. Bick, Marie McConkey, Vasan S. Ramachandran
Publikováno v:
Blood. 139:357-368
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic
Autor:
Anna-Maria Fink, Tobias Gaska, Barbara Eichhorst, Werner Freier, Clemens-Martin Wendtner, Can Zhang, Julia von Tresckow, Kirsten Fischer, Ursula Vehling-Kaiser, Eugen Tausch, Stephan Stilgenbauer, Marcel Reiser, Martina Stauch, Michael J. Eckart, Sandra Robrecht, Petra Langerbeins, Moritz Fürstenau, Paula Cramer, Rudolf Schlag, Lothar Müller, Karl-Anton Kreuzer, Michael Hallek, Christina Balser, Othman Al-Sawaf
Publikováno v:
Blood. 139:177-187
Observation is the current standard of care for patients with early-stage asymptomatic chronic lymphocytic leukemia (CLL), as chemotherapy-based interventions have failed to prolong survival. We hypothesized that early intervention with ibrutinib wou
Publikováno v:
Blood. 139:118-133
Coagulation protease, factor VIIa (FVIIa), binds to endothelial cell protein C receptor (EPCR) and induces anti-inflammatory and endothelial barrier protective responses via protease-activated receptor-1 (PAR1)–mediated, biased signaling. Our recen
Autor:
Limin Wang, Julián Candia, Lichun Ma, Yongmei Zhao, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Kerry Dobbs, Peter D. Burbelo, Jeffrey I. Cohen, Ottavia M. Delmonte, Marshonna Forgues, Hui Liu, Helen F. Matthews, Elana Shaw, Michael A. Stack, Sarah E. Weber, Yu Zhang, Andrea Lisco, Irini Sereti, Helen C. Su, Luigi D. Notarangelo, Xin Wei Wang
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic respiratory infectious disease COVID-19. However, clinical manifestations and outcomes differ significantly among COVID-19 patients, ranging from asymptomati