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Autor:
Yvonne Opanga, Aisha Zuheri, Lillian Nkinda, Seth C Inzaule, Maghimbi Abubakar, Anne Kamau, Patience Oduor, Steven Lema, Sibhatu Biadgilign, Peter Memiah, Mtebe Majigo, Cyprien Baribwira, Felix Humwa
Publikováno v:
Journal of Interferon & Cytokine Research. 41:291-301
There remains a dearth of data regarding the association between chronic inflammation and hypertension (HTN) in sub-Saharan Africa, a region that accounts for70% of the global burden of HIV infection. Therefore, we assessed the levels of biomarkers a
Autor:
Karla K. Rodgers, Gertrude Kyere-Davies, Asif Alam Chowdhury, Neha Chataut, Bhupinder Singh, Gaurav Kumar, Shanjana Awasthi, Negar S. Rahman, Jacob Beierle, Jun Xie, Vibhudutta Awasthi, Vijay Ramani
Publikováno v:
ImmunoHorizons
The TLR4-interacting SPA4 peptide suppresses inflammation. We assessed the structural and physicochemical properties and binding of SPA4 peptide to TLR4–MD2. We also studied the changes at the whole transcriptome level, cell morphology, viability,
Autor:
Vuong Cat Khanh, Hiromi Hamada, Motoo Osaka, Yun Hsuan Chang, Toshiharu Yamashita, Mana Obata-Yasuoka, Osamu Ohneda, Ngo Nhat Hoang, Mizuho Fukushige, Yuji Hiramatsu
Publikováno v:
Stem Cells and Development
Cytokine storm is recognized as one of the factors contributing to organ failures and mortality in patients with COVID-19. Due to chronic inflammation, COVID-19 patients with diabetes mellitus (DM) or renal disease (RD) have more severe symptoms and
Autor:
Yang Yang, Sahana Manohar-Sindhu, Thomas C. Foster, Daohong Zhou, Dmitry O. Traktuev, Yonghan He, Vivekananda Budamagunta
Publikováno v:
Aging (Albany NY)
Aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. We hypothesized that senescent cells (SnCs) play a central role in this age-associated pathology in part due to their expressio
Autor:
Chi Liu, Zhen Duan, Leyuan Wang, Ming Yang, Kai Zhou, Xizi Du, Mengping Wu, Lin Yuan, Yizhou Zou, Huijun Liu, Xiangping Qu, Mandie Liu, Yang Xiang, Yu Yang, Xiaoqun Qin
Publikováno v:
Journal of Cellular and Molecular Medicine
As the direct contacting site for pathogens and allergens, the mucosal barrier plays a vital role in the lungs and intestines. Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathophysiological
Publikováno v:
Human Cell. 34:1617-1628
Emergent studies reveal the roles of inflammatory cells and cytokines in the development of diabetic retinopathy (DR), which is gradually portrayed as a chronic inflammatory disease accompanied by metabolic disorder. Through the pathogenesis of DR, m
Autor:
Hai-Cun Zhou, Xiao-Qin Liang, Zhi-Chang Liu, Jian-Ping Long, Guanghui Zhao, Hong-Bin Liu, Xin-Yan Yan, Wenwen Yu, Xiao-Yan Du
Publikováno v:
International Reviews of Immunology. 41:4-18
Metabolite lactic acid has always been regarded as a metabolic by-product rather than a bioactive molecule. Recently, this view has changed since it was discovered that lactic acid can be used as a signal molecule and has novel signal transduction fu
Autor:
Shohei Hori, Ryuichi Murakami
Publikováno v:
International Immunology. 33:803-807
Regulatory T (Treg) cells that express the lineage-defining transcription factor Foxp3 play a pivotal role in establishing and maintaining immune and tissue homeostasis. Foxp3 serves as a highly connected ‘hub’, interacting with numerous genomic
Publikováno v:
Journal of Molecular Cell Biology
The prevailing coronavirus disease-19 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has presented some neurological manifestations including hyposmia, hypogeusia, headache, stroke, encephalitis, Guillain–Ba
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research
Journal of Immunology Research
The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM interacts with cells to regulate diverse functions, including differ