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Autor:
Paul Fernyhough, Eftekhar Eftekharpour
Publikováno v:
Antioxidants & Redox Signaling. 37:578-596
Significance. This review highlights the many intracellular processes generating reactive oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes. The major sources ...
Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Autor:
Ayesha Zia, Sarah H. O'Brien
Publikováno v:
Blood. 140:533-541
This review focuses on significant advances in the field of pediatric hemostasis and thrombosis, with a focus on published studies within the past decade. The evaluation and management of patients with excessive bleeding remain cornerstones of consul
Publikováno v:
Internal Medicine Journal. 52:1733-1740
Background Peripherally inserted central catheters (PICCs) are commonly used in cancer patients. PICC-associated upper limb venous thromboembolism (PaULVTE, non-deep and deep involving veins proximal to the brachial vein) and distant VTE (i.e. pulmon
Autor:
Vijay G. Sankaran, Deepa Bhojwani, C. Michel Zwaan, Nik F Nik-Abdul-Rashid, Josefine Palle, Jeffrey M Verboon, Stephanie DiTroia, Klas Raaschou-Jensen, Charlotte Guldborg Nyvold, Alan B. Cantor, Katherine R. Chao, Ronald M Kline, Henrik Hasle, Eigil Kjeldsen
Publikováno v:
Hasle, H, Kline, R M, Kjeldsen, E, Nik-Abdul-Rashid, N F, Bhojwani, D, Verboon, J M, DiTroia, S P, Chao, K R, Raaschou-Jensen, K, Palle, J, Zwaan, C M, Nyvold, C G, Sankaran, V G & Cantor, A B 2022, ' Germline GATA1s generating mutations predispose to leukemia with acquired trisomy 21 and Down syndrome-like phenotype ', Blood, vol. 139, no. 21, pp. 3159–3165 . https://doi.org/10.1182/blood.2021011463
Blood
Blood, 139(21), 3159-3165. American Society of Hematology
Blood
Blood, 139(21), 3159-3165. American Society of Hematology
Individuals with Down syndrome are at increased risk of myeloid leukemia in early childhood, which is associated with acquisition of GATA1 mutations that generate a short GATA1 isoform called GATA1s. Germline GATA1s-generating mutations result in con
Autor:
Giovanni Palladini, Giampaolo Merlini
Publikováno v:
Blood. 139:2918-2930
The treatment of patients with systemic light chain (AL) amyloidosis is a challenge to hematologists. Despite its generally small size, the underlying clone causes a rapidly progressing, often devastating multiorgan dysfunction through the toxic ligh
Autor:
Suelen Martins Perobelli, Chi L. Nguyen, Anastasia I. Kousa, Jonathan U. Peled, Joseph C. Sun, Justin R. Cross, Eli Zamir, Robert R. Jenq, Sebastien Monette, Melody Smith, Melissa D. Docampo, Ann E. Slingerland, Christoph K. Stein-Thoeringer, Clair D. Geary, Itamar Greenfield, Marina Burgos da Silva, Sophia R. Lieberman, Nicole Lee, Yusuke Shono, Gabe K Armijo, Emmanuel A Dwomoh, Kate A Markey, Marcel R M Rm van den Brink, Amina Lazrak, Katherine B Nichols, Santosha Vardhana
Publikováno v:
Blood
The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein-coupled receptors GPR43 and GPR109A (HCAR2), with varying affi
Publikováno v:
Blood. 139:2130-2144
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulatin
Autor:
Pooria Fallah, Huling Lyu, Dan Burch, Deborah Foyle, Thomas G.H. Diekwisch, Xianghong Luan, Xiaofeng Zhou, Mirali Pandya
Publikováno v:
Semin Cell Dev Biol
Periodontal disease is an inflammatory reaction of the periodontal tissues to oral pathogens. In the present review we discuss the intricate effects of a regulatory network of gene expression modulators, microRNAs (miRNAs), as they affect periodontal
Autor:
Nancy L. Bartlett, Felicia Gomez, Matthew Mosior, Malachi Griffith, Anne Fischer, Michelle Becker-Hapak, Mark P. Foster, Melissa M. Berrien-Elliott, Alina D. Schmidt, Marcus Watkins, Amanda F. Cashen, Kilannin Krysiak, Kami J. Maddocks, Nina D. Wagner-Johnston, Jingqin Luo, Obi L. Griffith, Zachary L. Skidmore, Todd A. Fehniger, Sweta Desai, Jeffrey P. Ward
Publikováno v:
Blood
New therapies are needed for patients with relapsed/refractory (rel/ref) diffuse large B-cell lymphoma (DLBCL) who do not benefit from or are ineligible for stem cell transplant and chimeric antigen receptor therapy. The CD30-targeted, antibody-drug