Zobrazeno 31 - 40
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Autor:
Daoguang Yan, Yu Huang, Wenbin Zhong, Xiuye Cao, Guoping Pan, Meng-Yang Xu, Qun Niu, Qing Yi, Xiaoqin Feng, Mingchuan Li
Publikováno v:
Blood. 139:1052-1065
Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cel
Autor:
Ross L. Levine, Jing Zhang, Fabao Liu, Alexis Vedder, Xin Gao, Sergey Nikolaev, Mrinal M. Patnaik, Abhishek A. Mangaonkar, Yun Zhou, Kalyan Vara Ganesh Nadiminti, Anthony M. Hunter, Terra L. Lasho, Wei Xu, Evan Flietner, Erik A. Ranheim, Xiaona You, Ruiqi Liao, Klaus Geissler, Eric Padron, Nathalie Droin, Guangyao Kong, Moritz Binder, Eric Solary, Maria E. Balasis, Christy Finke, Britta Will, Omar Abdel-Wahab, Adhithi Rajagopalan, Zhi Wen, David T. Yang
Publikováno v:
Blood
Mutations in chromatin regulator ASXL1 are frequently identified in myeloid malignancies, in particular ∼40% of patients with chronic myelomonocytic leukemia (CMML). ASXL1 mutations are associated with poor prognosis in CMML and significantly co-oc
Publikováno v:
Blood
The Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the causal agent of Kaposi sarcoma (KS), but is also pathogenetically related to several lymphoproliferative disorders, including primary effusion lymphoma (PEL)/ext
Autor:
Noopur Raje, Chukwuamaka Onyewadume, Cristina Panaroni, Ka Tat Siu, Keertik Fulzele, Tomoaki Mori, Allison Maebius
Publikováno v:
Blood
Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein multiple myeloma (MM) originates and resides. However, the nature of the interaction between MM cells and adipocytes remains unclear. Cancer-associated adipocytes suppor
Publikováno v:
Journal of Leukocyte Biology. 112:491-498
Sepsis manifests due to the host’s dysregulated immune response to an infection. High dose ascorbic acid (AA) has emerged as a potential treatment of sepsis, yet little is known regarding how ascorbic acid influences the immune system in sepsis, su
Autor:
Muriel Roth, Josée Golay, Rut Valgardsdottir, Rachele Alzani, Sabrina Cribioli, Antonella Interdonato, Mirco Sana, Martine Duonor-Cérutti, Sylvie Choblet
Publikováno v:
Cytotherapy. 24:161-171
Background aims The authors describe here a novel therapeutic strategy combining a bispecific antibody (bsAb) with cytokine-induced killer (CIK) cells. Methods The authors have designed, produced and purified a novel tetravalent IgG1-like CD20 × CD5
Autor:
Charles A. Parkos, Jennifer C. Brazil
Publikováno v:
Mucosal Immunology
Glycans are essential cellular components that facilitate a range of critical functions important for tissue development and mucosal homeostasis. Furthermore, specific alterations in glycosylation represent important diagnostic hallmarks of cancer th
Autor:
Jeff P. Sharman, Peter Trask, Yeung-Chul Mun, Anthony Masaquel, Habte A. Yimer, Alexey V. Danilov, John M. Burke, Sunil Babu, Jia Li, Michael Boxer
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:121-128
Introduction: Longitudinal changes in health-related quality of life (HRQoL) are important in patients with chronic lymphocytic leukemia (CLL). GIBB (NCT02320487) is an open-label, single-arm phase II study of obinutuzumab (GA101; G) in combination w
Autor:
Sebastian Wolf, Constanze Schneider, Roland Schmitz, Kwang Seok Lee, Mikolaj Slabicki, Hans Christian Reinhardt, Henning Urlaub, Craig J. Thomas, Anne C. Wilke, Hubert Serve, Fernando Kreuz, Joshua D. Rabinowitz, Dominique Jahn, Michele Ceribelli, Christian Brandts, Kimberly Stegmaier, Matthew G. Vander Heiden, Caroline A. Lewis, Thomas Oellerich, Kamil Bojarczuk, Thorsten Zenz, Daniel J. Hodson, Sara A Rieke, Yana Pikman, James Q Wang, Xincheng Xu, Michael Engelke, Hahn Kim, Hanibal Bohnenberger, Zana A. Coulibaly, Clemens A Schmitt, Federico Comoglio, James D. Phelan, Louis M. Staudt, Carmen Doebele, Sebastian Scheich, Björn Chapuy, Frank Schnuetgen, Gero Knittel, Frances A. Tosto, Philipp Stroebel, Alena Zindel, Björn Häupl, Philipp Stauder, Thanh Hung Dang
Publikováno v:
Blood
Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, chemotherapy-related toxicity and disease relapse remain major clinical
Autor:
Andrea Mayado, Iván Álvarez-Twose, María Jara-Acevedo, Ana Gabriela Henriques, Javier I. Muñoz-González, Laura Sánchez-Muñoz, Alba Pérez-Pons, Alberto Orfao, Carolina Caldas, Lidia Torres-Rivera, Andrés C. García-Montero, Almudena Matito
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Circulating tumor mast cells (CTMCs) have been identified in the blood of a small number of patients with advanced systemic mastocytosis (SM). However, data are limited about their frequency and prognostic impact in patients with MC activation syndro