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Autor:
Paul Fernyhough, Eftekhar Eftekharpour
Publikováno v:
Antioxidants & Redox Signaling. 37:578-596
Significance. This review highlights the many intracellular processes generating reactive oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes. The major sources ...
Publikováno v:
Journal of Investigative Dermatology. 142:774-780
Regulatory T cells (Tregs) play a critical role in regulating tissue inflammation. Reduced Treg numbers and/or suppressive function contribute to autoimmune disease. Tregs can adopt the transcriptional programming of T helper (Th) type-1/2/17 cells t
Autor:
Thomas S. McCormick, Pushpa Pandiyan
Publikováno v:
Journal of Investigative Dermatology. 142:867-875
This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3+ regulatory T cells in the context
Autor:
Atsuko Shono, Coenraad K van Kalken, Peter J. van der Spek, Eric P Krenning, Toru Kotani, Djo Hasan
Publikováno v:
Purinergic Signalling
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Purinergic Signalling, 18(1), 13-59. Springer Netherlands
Hyperinflammation plays an important role in severe and critical COVID-19. Using inconsistent criteria, many researchers define hyperinflammation as a form of very severe inflammation with cytokine storm. Therefore, COVID-19 patients are treated with
Publikováno v:
Journal of Investigative Dermatology. 142:823-833
Dysregulation in the phenotype and function of neutrophils may play important roles in the initiation and perpetuation of autoimmune responses, including conditions affecting the skin. Neutrophils can have local and systemic effects on innate and ada
Publikováno v:
Journal of Investigative Dermatology. 142:760-767
The core function of the immune response is to distinguish between self and foreign. The multiorgan human autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/autoimmune polyendocrine syndrome type 1) is an examp
Autor:
Harpreet Rai, Taylor A Minato, Coco Ng, Bruce M. McManus, Al Rohet Hossain, Paul J. Hanson, Jeremy A. Hirota, Victoria A Chen, Felicia Liu-Fei, Kjetil Ask
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
The prevalence and contribution of cardiotropic viruses to various expressions of heart failure are increasing, yet primarily underappreciated and underreported due to variable clinical syndromes, a lack of consensus diagnostic standards and insuffic
Autor:
Ling-Sai Chang, Ying-Hsien Huang, Mindy Ming-Huey Guo, Chiao-Lun Chu, Ho-Chang Kuo, Li-Feng Bu, Kuang-Den Chen, Chi-Hsiang Chu, Shih-Feng Liu, Chih-Hung Lee
Publikováno v:
Journal of Investigative Dermatology. 142:104-113
In this study, we investigated the changes in global methylation status and its functional relevance in childhood atopic dermatitis (AD). Differences in epigenome-scale methylation events in peripheral blood associated with childhood AD were screened
Autor:
Caroline A. Nelson, Mary M. Tomayko
Publikováno v:
Journal of Investigative Dermatology. 141:2777-2780
Pemphigus is a debilitating autoimmune blistering disorder mediated by IgG autoantibodies to desmosomal cadherins that requires novel steroid-sparing therapies. In this phase 1b/2 trial reported by Werth et al. (2021), the FcRn inhibitor ALXN1840 ind
Autor:
Tamihiro Kawakami, Haruki Shida, Daigo Nakazawa, Utano Tomaru, Tatsuro Okano, Sora Takeuchi, Akihiro Ishizu, Takafumi Kadono
Publikováno v:
Pathobiology. 89(1):23-28
Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellu