Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mandy L. Ford"'
Publikováno v:
iScience, Vol 23, Iss 4, Pp-(2020)
iScience
iScience
Summary Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells.
Publikováno v:
JCI insight. 3(1)
Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are differentially controlled by cosignaling receptors such as CD28 and CTLA-4. Treatment with a
Autor:
Lumelle A. Schneeweis, Steven G. Nadler, Danya Liu, Dawn K. Stetsko, Scott M. Krummey, Maylene E. Wagener, I. Raul Badell, Mandy L. Ford, Suzanne J. Suchard
Publikováno v:
The Journal of Experimental Medicine
Blockade of CD28 signals results in the up-regulation of 2B4 on primary CD8+ effectors and plays a critical role in controlling antigen-specific CD8+ T cell responses.
Mounting evidence in models of both autoimmunity and chronic viral infection
Mounting evidence in models of both autoimmunity and chronic viral infection
Publikováno v:
The Journal of Immunology. 181:1760-1766
Current models of T cell activation focus on the kinetics of TCR-ligand interactions as the central parameter governing T cell responsiveness. However, these kinetic parameters do not adequately predict all T cell behavior, particularly the response
Autor:
Christian P. Larsen, Allan D. Kirk, Mandy L. Ford, Minqing Song, Maylene E. Wagener, Ivana R. Ferrer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(51)
Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation. Indeed, CD40 pathway blockade remains one of the most powerful methods of prolonging graft survival in models of tra
Autor:
Mandy L. Ford, Tamara L. Floyd, Allan D. Kirk, Christian P. Larsen, Maylene E. Wagener, Natalie M. Reisman
Publikováno v:
Blood. 118(22)
Despite encouraging results using lymphocyte function antigen-1 (LFA-1) blockade to inhibit BM and solid organ transplantation rejection in nonhuman primates and humans, the precise mechanisms underlying its therapeutic potential are still poorly und