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Autor:
Carolin M. Lieber, Richard K. Plemper
Publikováno v:
DNA and cell biology. 41(8)
The COVID-19 pandemic has highlighted the urgent need for the development of broad-spectrum antivirals to enhance preparedness against future spillover of zoonotic viruses with pandemic potential into the human population. Currently, the direct-actin
Autor:
Sarah R. Ball, Julius S. P. Adamson, Michael A. Sullivan, Manuela R. Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H. Kwan, André D. J. McKenzie, Eryn L. Werry, Tuomas P. J. Knowles, Michael Kassiou, Georg Meisl, Matthew H. Todd, Peter J. Rutledge, Margaret Sunde
Publikováno v:
ACS Chemical Neuroscience. 14:87-98
Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small molecules to limit the conversion of monomeric a
Autor:
Jun Seop Yun, Hyeeun Song, Nam Hee Kim, So Young Cha, Kyu Ho Hwang, Jae Eun Lee, Cheol-Hee Jeong, Sang Hyun Song, Seonghun Kim, Eunae Sandra Cho, Hyun Sil Kim, Jong In Yook
Publikováno v:
Molecules and Cells. 45:911-922
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosph
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-18
Brevilin A (BA), a sesquiterpene lactone isolated from Centipeda minima herb, has been identified to exhibit potent anticancer activity. However, the potential pharmacological effect and mechanism of BA in regulating endothelial cell (EC) angiogenesi
Autor:
Zijian Zheng, Shushan Zhang, Hanwen Zhang, Zhongzheng Gao, Xiangrong Wang, Xinjie Liu, Cheng Xue, Longping Yao, Guohui Lu
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-20
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that manifests as motor and nonmotor symptoms due to the selective loss of midbrain DArgic (DA) neurons. More and more studies have shown that pathological reactions initiated by au
Autor:
Masamitsu Mikami, Tatsuya Masuda, Takuya Kanatani, Mina Noura, Katsutsugu Umeda, Hidefumi Hiramatsu, Hirohito Kubota, Tomoo Daifu, Atsushi Iwai, Etsuko Yamamoto Hattori, Kana Furuichi, Saho Takasaki, Sunao Tanaka, Yasuzumi Matsui, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Yasumichi Kuwahara, Tomoko Iehara, Hajime Hosoi, Yoichi Imai, Junko Takita, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
Publikováno v:
Molecules and Cells. 45:886-895
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report the imp
Autor:
Hyunju Park, Jung A Shin, Jiwoo Lim, Seulgi Lee, Jung-Hyuck Ahn, Jihee Lee Kang, Youn-Hee Choi
Publikováno v:
Molecules and Cells. 45:950-962
Aging is a major risk factor for common neurodegenerative diseases. Although multiple molecular, cellular, structural, and functional changes occur in the brain during aging, the involvement of caveolin-2 (Cav-2) in brain ageing remains unknown. We i
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-39
Adaptin ear-binding coat-associated protein 2 (NECAP2) belongs to the family of proteins encoding adaptin-ear-binding coat-associated proteins. However, its immune effect on tumors and its microenvironment are still unclear. Here, we systematically e
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-25
The liver is the largest digestive organ in the human body. The increasing incidence of chronic liver fibrosis is one of the major health challenges in the world. Liver fibrosis is a wound-healing response to acute or chronic cellular damage of liver
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-14
Peripheral nerve injury (PNI) is a major clinical problem that may lead to different levels of sensory and motor dysfunction including paralysis. Due to the high disability rate and unsatisfactory prognosis, the exploration and revealment of the mech