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Autor:
Carolin M. Lieber, Richard K. Plemper
Publikováno v:
DNA and cell biology. 41(8)
The COVID-19 pandemic has highlighted the urgent need for the development of broad-spectrum antivirals to enhance preparedness against future spillover of zoonotic viruses with pandemic potential into the human population. Currently, the direct-actin
Autor:
Jun Seop Yun, Hyeeun Song, Nam Hee Kim, So Young Cha, Kyu Ho Hwang, Jae Eun Lee, Cheol-Hee Jeong, Sang Hyun Song, Seonghun Kim, Eunae Sandra Cho, Hyun Sil Kim, Jong In Yook
Publikováno v:
Molecules and Cells. 45:911-922
A structural protein of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), nucleocapsid (N) protein is phosphorylated by glycogen synthase kinase (GSK)-3 on the serine/arginine (SR) rich motif located in disordered regions. Although phosph
Autor:
Masamitsu Mikami, Tatsuya Masuda, Takuya Kanatani, Mina Noura, Katsutsugu Umeda, Hidefumi Hiramatsu, Hirohito Kubota, Tomoo Daifu, Atsushi Iwai, Etsuko Yamamoto Hattori, Kana Furuichi, Saho Takasaki, Sunao Tanaka, Yasuzumi Matsui, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Tatsutoshi Nakahata, Yasumichi Kuwahara, Tomoko Iehara, Hajime Hosoi, Yoichi Imai, Junko Takita, Hiroshi Sugiyama, Souichi Adachi, Yasuhiko Kamikubo
Publikováno v:
Molecules and Cells. 45:886-895
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report the imp
Autor:
Hyunju Park, Jung A Shin, Jiwoo Lim, Seulgi Lee, Jung-Hyuck Ahn, Jihee Lee Kang, Youn-Hee Choi
Publikováno v:
Molecules and Cells. 45:950-962
Aging is a major risk factor for common neurodegenerative diseases. Although multiple molecular, cellular, structural, and functional changes occur in the brain during aging, the involvement of caveolin-2 (Cav-2) in brain ageing remains unknown. We i
Autor:
Yosep Mo, Sung-Yoon Kang, Ji-Young Bang, Yujin Kim, Jiung Jeong, Eui-Man Jeong, Hye Young Kim, Sang-Heon Cho, Hye-Ryun Kang
Publikováno v:
Molecules and Cells. 45:833-845
Although asthma is a common chronic airway disease that responds well to anti-inflammatory agents, some patients with asthma are unresponsive to conventional treatment. Mesenchymal stem cells (MSCs) have therapeutic potential for the treatment of inf
Publikováno v:
Molecules and Cells. 45:792-805
Repairing damaged DNA and removing all physical connections between sister chromosomes is important to ensure proper chromosomal segregation by contributing to chromosomal stability. Here, we show that the depletion of non-SMC condensin I complex sub
Autor:
Yuxiao Yao, Weiping Han
Publikováno v:
Molecules and Cells. 45:781-788
Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysre
Autor:
Hae-Sim Park, Chang-Gyu Jung
Publikováno v:
Current Protein & Peptide Science. 23:714-720
Abstract: Hop Japanese (Hop J) pollen has been considered one of the major causative pollen allergens in Far East Asia in the autumn season. The sensitization rate, pollen count, and allergenicity of Hop J pollens are increasing in this region becaus
Publikováno v:
DNA and Cell Biology. 41:935-950
Extracellular vesicles (EVs) are nanoparticles that include exosomes, microvesicles, and apoptotic bodies; they interact with target cell surface receptors and transport contents, including mRNA, proteins, and enzymes into the cytoplasm of target cel
Autor:
Alberto Zamò, Elena Gerhard-Hartmann, German Ott, Ioannis Anagnostopoulos, David W. Scott, Andreas Rosenwald, Hilka Rauert-Wunderlich
Publikováno v:
Virchows Archiv. 481:935-943
The subclassification of diffuse large B-cell lymphoma (DLBCL) into germinal center B-cell-like (GCB) and activated B-cell-like (ABC) subtypes has become mandatory in the 2017 update of the WHO classification of lymphoid neoplasms and will continue t