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Autor:
Natálie Klubíčková, Michael Michal, Abbas Agaimy, Nina Zidar, Michal Pavlovský, Kenji Yorita, Petr Grossmann, Veronika Hájková, Nikola Ptáková, Petr Šteiner, Michal Michal
Publikováno v:
Virchows Archiv. 481:721-729
We report 7 cases of an indolent, variably myxoid tumor of the vocal cords, characterized by overt cellular atypia with large cells containing intranuclear and intracytoplasmic vacuoles, delicate curvilinear vessels, and sparse inflammatory infiltrat
Autor:
Olli Helminen, Jukka Melkko, Juha Saarnio, Eero Sihvo, Teijo Kuopio, Pasi Ohtonen, Joonas H. Kauppila, Tuomo J. Karttunen, Heikki Huhta
Publikováno v:
Virchows Archiv. 481:467-476
Barrett’s esophagus progresses to high-grade dysplasia or cancer along the well-established metaplasia-dysplasia-adenocarcinoma sequence. The aim of this study was to evaluate the value of p53, Ki67, and toll-like receptor 5 (TLR5) in prediction of
Autor:
Ziyad Alsugair, Vahan Kepenekian, Tanguy Fenouil, Olivier Glehen, Laurent Villeneuve, Sylvie Isaac, Juliette Hommell-Fontaine, Nazim Benzerdjeb
Publikováno v:
Virchows Archiv. 481:23-29
The differentiation between reactive mesothelial hyperplasia (RMH) and diffuse malignant peritoneal mesothelioma (DMPM) is challenging especially when applied on peritoneal small samples. The use of BRCA-associated protein 1 (BAP1) and methylthioaden
Autor:
Pavel Dundr, Barbora Bazalová, Michaela Bártů, Tjalling Bosse, Jana Drozenová, Pavel Fabian, Oluwole Fadare, Jitka Hausnerová, Radek Jakša, Jan Laco, Sigurd F. Lax, Radoslav Matěj, W. Glenn McCluggage, Gábor Méhes, Romana Michálková, Kristýna Němejcová, Naveena Singh, Simona Stolnicu, Petr Škapa, Marián Švajdler, Ivana Stružinská
Publikováno v:
Virchows Archiv, 481(2), 201-212. SPRINGER
We assessed the value of cytokeratin 17 (CK17) expression for the differential diagnosis between primary ovarian mucinous tumors and metastases from the gastrointestinal tract (GIT) and the significance of CK17 expression in a broad spectrum of prima
Publikováno v:
Virchows Archiv. 481:511-516
We report a case of primary rectal neoplasm with a novel DDX5-TFEB fusion in a 14-year-old boy. Histologically, the neoplasm was composed of epithelioid tumor cells with abundant clear to eosinophilic cytoplasm, arranged in nests with rich stromal ca
Autor:
Yigit Baykara, Ying Xiao, Dongfang Yang, Evgeny Yakirevich, Sara Maleki, Maria Garcia-Moliner, Li Juan Wang, Chiung-Kuei Huang, Shaolei Lu
Publikováno v:
Virchows Archiv. 481:31-39
Small-cell lung cancers (SCLC) and large-cell neuroendocrine carcinomas (LCNEC) are two types of high-grade pulmonary neuroendocrine carcinomas (NECs). Diagnostic neuroendocrine markers commonly include synaptophysin, chromogranin A, CD56, and insuli
Publikováno v:
Virchows Archiv. 480:1023-1030
The successful experiences of HER2 inhibitors in patients with HER2 ( +) breast cancer (BC) and advanced gastroesophageal adenocarcinoma (GEA) have encouraged us to continuously explore the HER2 status and its potential as a therapeutic target in pri
Autor:
Hye Won Hwang, Soon Auck Hong, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Jong-Han Yu, Se Kyung Lee, Soo Youn Cho, Eun Yoon Cho
Publikováno v:
Virchows Archiv. 480:749-758
The American Society of Clinical Oncology and College of American Pathologists guidelines for HER2 testing in breast cancer (BC) have been updated with more stringent criteria regarding immunohistochemistry (IHC) 2 + interpretation. The aim of our st
Autor:
Shih-Chiang, Huang, Kuang-Hua, Chen, Kwai-Fong, Ng, I-Chieh, Lin, Yi-Chun, Chao, Ta-Sen, Yeh, Huei-Chieh, Chuang, Tse-Ching, Chen
Publikováno v:
Virchows Archiv. 480:771-781
Gastric carcinoma showing an abrupt transition from a tubular to solid pattern is an unusual phenomenon reminiscent of dedifferentiation. The phenotypic and molecular characteristics of this transition are still unclear. We retrospectively collected
Autor:
Isidro, Machado, Gregory W, Charville, Akihiko, Yoshida, Samuel, Navarro, Alberto, Righi, Marco, Gambarotti, Katia, Scotlandi, José A, López-Guerrero, Antonio, Llombart-Bosch
Publikováno v:
Virchows Archiv. 480:909-917
Ewing sarcoma (ES) is an aggressive neoplasm with variable morphology. It has no specific immunoprofile or molecular signature. Neither CD99, NKX2.2 nor PAX7 immunoreactivity alone is completely specific, although diagnostic specificity improves when