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Autor:
Fatima Akram, Ikram ul Haq, Zuriat Jabbar, Rabia Akram, Ali Nawaz, Amna Aqeel, Noman Atique, Zeeshan Ahmed
Publikováno v:
Current Protein & Peptide Science. 22:599-619
Background: MicroRNAs (miRNA) belong to the substantial class of posttranscriptional gene regulators with decisive functions in typical cellular and disease progressions. They are short RNA molecules that are not translated into proteins but bind to
Publikováno v:
Current Protein & Peptide Science. 22:567-573
Background: Ovarian cancer is one of the leading causes of death worldwide. Polymers have low cytotoxicity and high functionalizability and are hence used for drug delivery systems, tissue engineering, and polymer therapeutics. In drug delivery syste
Publikováno v:
Molecular and Cellular Biochemistry. 477:605-619
Cervical and ovarian cancers contribute significantly to female morbidity and mortality worldwide. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, offers poor outcomes. There are many side effects t
Autor:
Gerard Dijkstra, Marijn C. Visschedijk, Remco J. Renken, Henk J. Buikema, Marco R. de Groot, Jacco J de Haan, Mathilde Jalving, Gursah Kats-Ugurlu, Sara Hone Lopez
Publikováno v:
Virchows Archiv
Virchows Archiv : an International Journal of Pathology, 479(6), 1119-1129. SPRINGER
Virchows Archiv : an International Journal of Pathology, 479(6), 1119-1129. SPRINGER
Colitis is a common, but poorly understood, adverse event of immune checkpoint inhibitors that are standard-of-care for an expanding range of cancer types. This explorative study aimed to describe the immune infiltrates in the colon from individuals
Autor:
Karen T Elvers, Maia Kavanagh Williamson, Massimo Caputo, Darryl J. Hill, Paolo Madeddu, Andrew D. Davidson, Elisa Avolio, Imre Berger, Rachel Milligan, Kapil Gupta, David T Arnold, Michele Carrabba, Fergus Hamilton, Rebecca R. Foster, Kathleen M Gillespie, Monica Gamez, Antonio Paolo Beltrami
Publikováno v:
Avolio, E, Carrabba, M, Milligan, R, Kavanagh Williamson, M, Beltrami, A P, Gupta, K, Elvers, K T, Gamez, M, Foster, R R, Gillespie, K M, Hamilton, F W, Arnold, D T, Berger, I, Davidson, A D, Hill, D J, Caputo, M & Madeddu, P R 2021, ' The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling : a potential non-infective mechanism of COVID-19 microvascular disease ', Clinical Science, vol. 135, no. 24, CS20210735, pp. 2667-2689 . https://doi.org/10.1042/CS20210735
Severe coronavirus disease 2019 (COVID-19) manifests as a life-threatening microvascular syndrome. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Spike (S) protein to engage with its receptors and infect host cells. To date
Autor:
Aryeong Choi, Yong Woo Jung, Seohoon Jin, Kyong Hoon Kim, Heonju Song, Sang Hoon Kim, Jaebong Jang, Hanbyeul Choi, Kyungim Kim
Publikováno v:
Molecules and Cells
Memory T (TM) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how TM cel
Publikováno v:
Molecular and Cellular Biochemistry. 477:585-592
OBJECTIVE Endoplasmic reticulum stress (ERS) might play a pivotal role in the persistence of metabolic syndrome (MS). Lipopolysaccharide (LPS) derived from various gram-negative bacteria could result in the ERS. Therefore, we aimed to investigate the
Autor:
Manuel B. Braga-Neto, Paulo Roberto Leitão de Vasconcelos, Flávia A. Santos, Gerly Anne de Castro Brito, Felipe Maciel, Renata Ferreira de Carvalho Leitão, Dulciene M.M. Queiroz, Michelle Oliveira, Antonio Brazil Viana-Júnior, Lucia L. B. C. Braga, Deiziane Viana da Silva Costa
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Background and Aims. First-degree relatives of gastric cancer patients are at increased risk of developing gastric cancer. Increased oxidative stress, including lipid peroxidation, has been associated with gastric carcinogenesis. Whether first-degree
Autor:
Hai Liu, Yiyang Hong, Guanyu Wang, Haozhe Li, Xingjian Dong, Jingjing Tao, Anyong Xie, Yili Feng, Yihong Wang, Zhenyu Liuyang, Qinghua Dong, Jing Zhang, Zhongyang Jiang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Radiation-induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long-term survival in cancer patients receiving radiotherapy, but until now, there have been n
Autor:
Cecilia S. Blengini, Karen Schindler
Publikováno v:
Biol Reprod
The purpose of meiosis is to generate developmentally competent, haploid gametes with the correct number of chromosomes. For reasons not completely understood, female meiosis is more prone to chromosome segregation errors than meiosis in males, leadi