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pro vyhledávání: ''
Autor:
John R. Speakman, Jasper M. A. de Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S. W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma, Daniel Hoffman, Sumei Hu, Annemiek M. Joosen, Jennifer L. Kaplan, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Marie Löf, Corby K. Martin, Eric Matsiko, Anine C. Medin, Erwin P. Meijer, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Susan B. Racette, David A. Raichlen, Eric Ravussin, Leanne M. Redman, Susan B. Roberts, Michael C. Rudolph, Luis B. Sardinha, Albertine J. Schuit, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Brian M. Wood, Jack A. Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Anura Kurpad, Amy H. Luke, Herman Pontzer, Matthew S. Rodeheffer, Jennifer Rood, Dale A. Schoeller, William W. Wong
Publikováno v:
Nature Metabolism, 5(4), 579-588. Springer Berlin
Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composi
Publikováno v:
Hooglugt, A, Klatt, O & Huveneers, S 2022, ' Vascular stiffening and endothelial dysfunction in atherosclerosis ', Current Opinion in Lipidology, vol. 33, no. 6, pp. 353-363 . https://doi.org/10.1097/MOL.0000000000000852
Purpose of reviewAging is an important risk factor for cardiovascular disease and is associated with increased vessel wall stiffness. Pathophysiological stiffening, notably in arteries, disturbs the integrity of the vascular endothelium and promotes
Publikováno v:
Current opinion in lipidology. 33(6):342-352
Purpose of the reviewOver the past decade, lipoprotein(a) [Lp(a)] made it to several consensus and guideline documents. This review aims to summarize the literature which underlies the various recommendations and compares recent European and North Am
Autor:
Tycho R. Tromp, Marina Cuchel
Publikováno v:
Current opinion in lipidology. 33(6):326-335
Purpose of reviewWe reviewed current and future therapeutic options for patients with homozygous familial hypercholesterolemia (HoFH) and place this evidence in context of an adaptable treatment algorithm.Recent findingsLowering LDL-C levels to norma
Publikováno v:
Nat Metab
Innate lymphoid cells (ILCs) are a family of predominantly tissue-resident lymphocytes that critically orchestrate immunity, inflammation, tolerance, and repair at barrier surfaces of the mammalian body. Heterogeneity among ILC subsets is comparable
Publikováno v:
Current Opinion in Lipidology. 33:319-325
Purpose of reviewTo review recent developments in the field of cholesteryl ester transfer protein (CETP) inhibition from clinical trials and genomic analyses which have the potential to impact future clinical programs.Recent findingsCETP plays an imp
Autor:
Liron Bar-Peled, Nora Kory
Publikováno v:
Nat Metab
Metabolism has historically been studied at the levels of whole cells, whole tissues and whole organisms. As a result, our understanding of how compartmentalization-the spatial and temporal separation of pathways and components-shapes organismal meta
Autor:
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu
Publikováno v:
Nature Metabolism. 4:1271-1286
Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and hyperlipidemia through modulating the gut microbiota in obese mice. Here we show that
Autor:
Qi-tao Chen, Zhi-yuan Zhang, Qiao-ling Huang, Hang-zi Chen, Wen-bin Hong, Tianwei Lin, Wen-xiu Zhao, Xiao-min Wang, Cui-yu Ju, Liu-zheng Wu, Ya-ying Huang, Pei-pei Hou, Wei-jia Wang, Dawang Zhou, Xianming Deng, Qiao Wu
Publikováno v:
Nature Metabolism. 4:1306-1321
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which f
Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan