Zobrazeno 31 - 40
of 5 303
pro vyhledávání: ''
Autor:
David J. Orlicky, Masanari Kuwabara, Ana Andres-Hernando, Miguel A. Lanaspa, Takahiko Nakagawa, Christina Cicerchi, Laura G. Sánchez-Lozada, Richard J. Johnson
Publikováno v:
Nat Metab
Umami refers to the savoury taste that is mediated by monosodium glutamate (MSG) and enhanced by inosine monophosphate and other nucleotides. Umami foods have been suggested to increase the risk for obesity and metabolic syndrome but the mechanism is
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context The identification and biological actions of pituitary-derived exosomes remain elusive. Objective This work aimed to validate production of exosomes derived from human and rat pituitary and elucidate their actions. Methods Isolated extracellu
Autor:
Michael Attwaters
Publikováno v:
Nature metabolism. 4(11)
Autor:
Christian Diener, Chengzhen L. Dai, Tomasz Wilmanski, Priyanka Baloni, Brett Smith, Noa Rappaport, Leroy Hood, Andrew T. Magis, Sean M. Gibbons
Publikováno v:
Nat Metab
Variation in the blood metabolome is intimately related to human health. Prior work has shown that host genetics and gut microbiome composition, combined, explain sizable, but orthogonal, components of the overall variance in blood metabolomic profil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6f3c7a9ca1964fcda85add4c6f58d1
https://europepmc.org/articles/PMC9691620/
https://europepmc.org/articles/PMC9691620/
Autor:
Elena Kempf, Kathrin Landgraf, Robert Stein, Martha Hanschkow, Anja Hilbert, Rami Abou Jamra, Paula Boczki, Gunda Herberth, Andreas Kühnapfel, Yu-Hua Tseng, Claudia Stäubert, Torsten Schöneberg, Peter Kühnen, N. William Rayner, Eleftheria Zeggini, Wieland Kiess, Matthias Blüher, Antje Körner
Publikováno v:
Nature metabolism. 4(12)
Here we report a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity. The mutation places ASIP under control of the ubiquitou
Autor:
Katherine E. Santostefano, Fiona M. Docherty, Shane P.M. Williams, JaeAnn M. Dwulet, Maria S. Hansen, Richard K.P. Benninger, Kent Riemondy, Holger A. Russ, Ali H. Shilleh, Roberto Castro-Gutierrez, Taylor M. Triolo, Mark A. Wallet, Lucas H. Armitage, Clayton E. Mathews
Publikováno v:
Diabetes
Stem cell–derived β-like cells (sBC) carry the promise of providing an abundant source of insulin-producing cells for use in cell replacement therapy for patients with diabetes, potentially allowing widespread implementation of a practical cure. T
Autor:
Robert Opitz, Adina Sophie Graffunder, Kostja Renko, Heike Biebermann, Sarah Paisdzior, Peter Kühnen
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 130:134-140
The monocarboxylate transporter 8 (MCT8) is a specific thyroid hormone transporter and plays an essential role in fetal development. Inactivating mutations in the MCT8 encoding gene SLC16A2 (solute carrier family 16, member 2) lead to the Allan-Hernd
Autor:
Wilson I. Gonsalves, Larry M. Karnitz, Sadae Hitosugi, Kiran Kurmi, Taro Hitosugi, Annapoorna Sreedhar, Elizabeth K. Wiese, Yuan-Ping Pang, Lindsey G. Andres-Beck, Sharon T. Loa
Publikováno v:
Nature metabolism
Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg effect. Here we show that
Autor:
Weiwei Liu, Yuhong Luo, Cen Xie, Frank J. Gonzalez, Oksana Gavrilova, Shoumei Yang, Henrique Bregolin Dias, Xuan Wu, Changtao Jiang, Xiaozhen Guo, Jie Cai, Kristopher W. Krausz, Shogo Takahashi, Lulu Sun
Publikováno v:
Nat Metab
MYC is a transcription factor with broad biological functions, notably in the control of cell proliferation. Here, we show that intestinal MYC regulates systemic metabolism. We find that MYC expression is increased in ileum biopsies from individuals
Autor:
Devika P. Bagchi, Ormond A. MacDougald
Publikováno v:
Diabetes
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate determination and differentiation have been extensively studied. Indeed