Zobrazeno 101 - 110
of 5 303
pro vyhledávání: ''
Publikováno v:
Diabetes
In order to meet its energy requirements, the heart has the intrinsic capability to metabolize a wide range of energy substrates. In normal conditions, the heart favors fatty acids as the main energetic substrate, followed by carbohydrates, ketone bo
Publikováno v:
Nat Metab
Unhealthful lifestyle factors, such as obesity, disrupt organismal homeostasis and accelerate cancer pathogenesis, partly through metabolic and immunological dysregulation. Exercise is a prototypical strategy that maintains and restores homeostasis a
Autor:
David A. Beebe, Gregg D. Cappon, Michelle Clasquin, Marc K. Hellerstein, Norimitsu Shirai, William J. Reagan, Zhongyuan Sun, Katherine Hales, Gabriele E. Sonnenberg, Jeffrey A. Pfefferkorn, Theodore J. Schmahai, Nicholas B. Vera, Marcy Matthews, Trenton T. Ross, Clare Buckeridge, Enida Ziso Qejvanaj, Kenneth L. Kelly, Shoh Asano, Santos Carvajal-Gonzalez, William P. Esler, Paul A. Amor, Kelvin W. Li, Arthur Bergman
Publikováno v:
Nature Metabolism. 2:1163-1178
Acetyl-CoA carboxylase (ACC) catalyses the first step of de novo lipogenesis (DNL). Pharmacologic inhibition of ACC has been of interest for therapeutic intervention in a wide range of diseases. We demonstrate here that ACC and DNL are essential for
Publikováno v:
Journal of Diabetes Investigation
Good health depends on the maintenance of metabolic flexibility, which in turn is dependent on the maintenance of regulatory flexibility of a large number of regulatory enzymes, but especially the pyruvate dehydrogenase complex (PDC), because of its
Publikováno v:
Diabetologia
All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in type 2 diabetes. Deeper understanding of the coupling mechanisms that link glucose metabolism
Autor:
Prashanth Vallabhajosyula, Ming Yu, Wei Wang, Negin Noorchashm Griffith, Chengyang Liu, Divyansh Agarwal, James F. Markmann, Ali Naji, Omaida C. Velazquez, Bernhard J. Hering, Laxminarayana Korutla, Catherine Lee May, Klaus H. Kaestner
Publikováno v:
Nature metabolism
The intrahepatic milieu is inhospitable to intraportal islet allografts1–3, limiting their applicability for the treatment of type 1 diabetes. Although the subcutaneous space represents an alternate, safe and easily accessible site for pancreatic i
Publikováno v:
Diabetologia
The islet of Langerhans is a complex endocrine micro-organ consisting of a multitude of endocrine and non-endocrine cell types. The two most abundant and prominent endocrine cell types, the beta and the alpha cells, are essential for the maintenance
Autor:
Jason D. Russell, Joshua J. Coon, Paul D. Hutchins, Donald S. Stapleton, Alan D. Attie, Mary E. Rabaglia, Katherine A. Overmyer, Thiru R. Reddy, Gregory R. Keele, Gary A. Churchill, Kathryn L. Schueler, Mark P. Keller, Duy Pham, Vanessa Linke, Karl W. Broman, Daniel M. Gatti, Edna A. Trujillo, Emily M. Cushing, Dain R. Brademan, Ian J. Miller
Publikováno v:
Nature metabolism
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively annotating lipid species and their genetic basis. Mass spectrometry-based discovery lipidomics offers the potential to globally survey lipids and t
Autor:
Roland Nilsson
Publikováno v:
Nature Metabolism. 4:1089-1090
Autor:
Anna L. Gloyn, Mark Ibberson, Piero Marchetti, Alvin C. Powers, Patrik Rorsman, Maike Sander, Michele Solimena
Publikováno v:
Nature metabolism. 4(8)
Detailed characterization of human pancreatic islets is key to elucidating the pathophysiology of all forms of diabetes, especially type 2 diabetes. However, access to human pancreatic islets is limited. Pancreatic tissue for islet retrieval can be o