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Autor:
Zhao Zhang, Man Jiang, Moubin Lin, Jiayin Peng, Hailong Wu, Yiao Jiang, Liya Ma, Dong Gao, Yun Zhao, Jiawen Song, Jia Wang, Juan He, Yuang Wang
Publikováno v:
Nat Metab
The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid metabolism and related diseases. However, the underlying mechanisms are poorly understood. Here, we show that the Hh signalling pathway induces a previously undefine
Autor:
David J. Orlicky, Masanari Kuwabara, Ana Andres-Hernando, Miguel A. Lanaspa, Takahiko Nakagawa, Christina Cicerchi, Laura G. Sánchez-Lozada, Richard J. Johnson
Publikováno v:
Nat Metab
Umami refers to the savoury taste that is mediated by monosodium glutamate (MSG) and enhanced by inosine monophosphate and other nucleotides. Umami foods have been suggested to increase the risk for obesity and metabolic syndrome but the mechanism is
Autor:
Weiwei Liu, Yuhong Luo, Cen Xie, Frank J. Gonzalez, Oksana Gavrilova, Shoumei Yang, Henrique Bregolin Dias, Xuan Wu, Changtao Jiang, Xiaozhen Guo, Jie Cai, Kristopher W. Krausz, Shogo Takahashi, Lulu Sun
Publikováno v:
Nat Metab
MYC is a transcription factor with broad biological functions, notably in the control of cell proliferation. Here, we show that intestinal MYC regulates systemic metabolism. We find that MYC expression is increased in ileum biopsies from individuals
Autor:
Joshua W. Goyert, Ho-Joon Lee, Sumeet Solanki, Matthew G. Vander Heiden, Samuel A. Kerk, Brian T. Do, Costas A. Lyssiotis, Yatrik M. Shah, Brandon Chen, Jason R. Spence, Michael K. Dame, Cristina Castillo, Xiang Xue, Peggy P. Hsu, Andrew J. Schwartz, Samira Lakhal-Littleton, Rashi Singhal
Publikováno v:
Nature metabolism
Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling and metabolically leverages iron are poorly understood. We demonstrate that the liver-derived, endocrine regulator of systemi
Autor:
Hannah Prendeville, Cathal Harmon, Nika N. Danial, Anita Reddy, Edward T. Chouchani, Accalia Fu, Nhien V. Tran, Ryan Garrity, Lydia Lynch, Steven P. Gygi, Evanna L. Mills, John Szpyt, Haopeng Xiao, Mark P. Jedrychowski, Gary A. Bradshaw
Publikováno v:
Nat Metab
Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD and is thought to contribute to tissue fibrosis and disease path
Autor:
Nicolas Skuli, M. Celeste Simon, Romain Riscal, Itzhak Nissim, Jun Song, Jason Godfrey, Hong Xie
Publikováno v:
Nature metabolism
Glycogen accumulation is a highly consistent, distinguishable characteristic of clear cell renal cell carcinoma (ccRCC)1. While elevated glycogen pools might be advantageous for ccRCC cells in nutrient-deprived microenvironments to sustain tumour via
Publikováno v:
Diabetologia
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over the past 50 years, elucidation of the insulin signalling network has provided important mechanistic insights into the abnormalities of glucose, lipid and p
Autor:
Thomas J. LaSalle, Carlos Sebastian, Begoña Gimenez-Cassina Lopez, Itay Tirosh, Jee-Eun Choi, Giórgia Gobbi da Silveira, Leif W. Ellisen, Walid M. Abdelmoula, Anna L.K. Gonye, Nathalie Y. R. Agar, Raul Mostoslavsky, Kenneth N. Ross, Gregory R. Wojtkiewicz, Christina M. Ferrer, Srinivas Vinod Saladi, Ruben Boon, Ruslan I. Sadreyev, Salvador Aznar Benitah, Murat Cetinbas, Moshe Sade-Feldman, Gloria Pascual, Caroline A. Lewis, Nir Hacohen, Michael S. Regan
Publikováno v:
Nature metabolism
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
Head and Neck Squamous Cell Carcinoma (HNSCC) remains among the most aggressive human cancers. Tumor progression and aggressiveness in SCC are largely driven by Tumor Propagating Cells (TPCs). Aerobic glycolysis, also known as the Warburg Effect, rep
Autor:
Mark P. Jedrychowski, Pedro Latorre-Muro, Christopher F. Bennett, Kamar Reda, Steven P. Gygi, Elizabeth A. Perry, Richard Porter Ladley, Katherine E. O’Malley, Chi Luo, Eduardo Balsa, Andrew G. Myers, Peter M. Wright, Pere Puigserver
Publikováno v:
Nature metabolism
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from mutations in nuclear or mitochondrial DNA genes encoding mitochondrial proteins1,2. MDs cause pathologies with severe tissue damage and ultimately death3,4. There are
Publikováno v:
Diabetes 70, 303-312 (2021)
Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We