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Autor:
Amélie Fradet-Turcotte, Daniel Durocher, Natasha Chaudhary, Anne Margriet Heijink, Salomé Adam, Sylvie M. Noordermeer, Alana Sherker
Publikováno v:
EMBO Reports, 22(12). WILEY
EMBO Reports
EMBO Reports
The tumor suppressor BRCA1 accumulates at sites of DNA damage in a ubiquitin‐dependent manner. In this work, we revisit the role of RAP80 in promoting BRCA1 recruitment to damaged chromatin. We find that RAP80 acts redundantly with the BRCA1 RING d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77b907f13feee402844efe9db9b476
https://doi.org/10.15252/embr.202153679
https://doi.org/10.15252/embr.202153679
Publikováno v:
EMBO Rep
Replication across oxidative DNA lesions can give rise to mutations that pose a threat to genome integrity. How such lesions, which escape base excision repair, get removed without error during replication remains unknown. Our PCNA-based screen to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89919ee4e5b6d994be43bef3b4724b0
https://europepmc.org/articles/PMC7271331/
https://europepmc.org/articles/PMC7271331/
Autor:
Marie-Josèphe Giraud-Panis, Jia-Xing Yue, Liudmyla Lototska, Nicola J. Royle, Jing Li, Jing Ye, Zhou Songyang, Aaron Mendez-Bermudez, Gianni Liti, Eric Gilson
Publikováno v:
EMBO Reports
EMBO Reports, EMBO Press, 2020, 21 (4), ⟨10.15252/embr.201949076⟩
EMBO Reports, EMBO Press, 2020, 21 (4), ⟨10.15252/embr.201949076⟩
Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non‐homologous end joining (NHEJ) and consequently telomere fusions, its role at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edd1baa5852ef7a5e5d873b966d59f5
https://hal.archives-ouvertes.fr/hal-03013736
https://hal.archives-ouvertes.fr/hal-03013736
Autor:
Daniël O. Warmerdam, Bram van den Broek, Rob M. F. Wolthuis, Haico van Attikum, Ignacio Alonso-de Vega, Raimundo Freire, René H. Medema, Magdalena B. Rother, Wouter W. Wiegant, Veronique A. J. Smits
Publikováno v:
EMBO Reports, 21(1). Wiley-Blackwell
Warmerdam, D O, Alonso-de Vega, I, Wiegant, W W, van den Broek, B, Rother, M B, Wolthuis, R M F, Freire, R, van Attikum, H, Medema, R H & Smits, V A J 2020, ' PHF6 promotes non-homologous end joining and G2 checkpoint recovery ', EMBO Reports, vol. 21, no. 1 . https://doi.org/10.15252/embr.201948460
EMBO Reports. WILEY
EMBO Reports
EMBO Reports, 21(1). WILEY
Warmerdam, D O, Alonso-de Vega, I, Wiegant, W W, van den Broek, B, Rother, M B, Wolthuis, R M F, Freire, R, van Attikum, H, Medema, R H & Smits, V A J 2020, ' PHF6 promotes non-homologous end joining and G2 checkpoint recovery ', EMBO Reports, vol. 21, no. 1 . https://doi.org/10.15252/embr.201948460
EMBO Reports. WILEY
EMBO Reports
EMBO Reports, 21(1). WILEY
The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library of chromatin regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209dede4d5487259235a1a940226125b
https://hdl.handle.net/1887/3213900
https://hdl.handle.net/1887/3213900
Autor:
Connor Arkinson, Laura Spagnolo, Mairi Clarke, Helen Walden, Martin L. Rennie, James Streetley, Kimon Lemonidis, Viduth K. Chaugule
Publikováno v:
EMBO reports
EMBO Reports
EMBO Reports
The Fanconi anaemia (FA) pathway is a dedicated pathway for the repair of DNA interstrand crosslinks and is additionally activated in response to other forms of replication stress. A key step in the FA pathway is the monoubiquitination of each of the
Publikováno v:
Cell Cycle. 16:968-978
Viruses can interact with host cell molecules responsible for the recognition and repair of DNA lesions, resulting in dysfunctional DNA damage response (DDR). Cells with inefficient DDR are more vulnerable to therapeutic approaches that target DDR, t
Publikováno v:
Cell Cycle
Cell Cycle, Taylor & Francis, 2016, 15 (16), pp.2174-2182. ⟨10.1080/15384101.2016.1196302⟩
Cell Cycle, Taylor & Francis, 2016, 15 (16), pp.2174-2182. ⟨10.1080/15384101.2016.1196302⟩
International audience; Multiple myeloma (MM) is still an incurable hematological malignancy. Despite recent progress due to new anti-myeloma agents, the pathology is characterized by a high frequency of de novo or acquired resistance. Delineating th
Autor:
Fernando Luna-Maldonado, Rodrigo González-Barrios, Julia Mendoza, Carlo Cortés-González, Franz Pruefer, Miguel Santibáñez, Rodrigo E. Cáceres-Gutiérrez, Eunice Fabián-Morales, Nancy Reynoso, Monserrat Justo-Garrido, Clementina Castro-Hernández, Marco A. Andonegui, Luis A. Herrera, Guadalupe Domínguez-Gómez, Miguel Ramirez-Otero, Ángela Downie-Ruíz, José Díaz-Chávez, Alejandro López-Saavedra
Publikováno v:
Cell Cycle
Background: Prolonged mitotic arrest in response to anti-cancer chemotherapeutics, such as DNA-damaging agents, induces apoptosis, mitotic catastrophe, and senescence. Disruptions in mitotic checkpoints contribute resistance to DNA-damaging agents in
The tumor suppressor p53, and the cyclin-dependent kinase inhibitor Ink4c, have been both implicated in spermatogenesis control. Both p53-/- and Ink4c-/- single knockout male mice are fertile, despite testicular hypertrophy, Leydig cell differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a3c318d993194f3edb4e8b1efaedc0
https://europepmc.org/articles/PMC5969541/
https://europepmc.org/articles/PMC5969541/
Autor:
Aleksandra Lezaja, Matthias Altmeyer
Publikováno v:
Cell Cycle
Replication stress is a major source of DNA damage and an important driver of cancer development. Replication intermediates that occur upon mild forms of replication stress frequently escape cell cycle checkpoints and can be transmitted through mitos