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Publikováno v:
EMBO Rep
Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to amino acid restriction, which impede the latter's clinical development. Here we show that M
Autor:
Paul B. Harvilla, Ninkka Tamot, Adam Zwolak, Jason Ho, Matthew D. Truppo, Rajitha Doddareddy, Tong-Yuan Yang, M. Jack Borrok, Ian White, Chowdhury Partha, Qun Jiao, Rajkumar Ganesan, Brian Geist
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The global health crisis and economic tolls of COVID-19 necessitate a panoply of strategies to treat SARS-CoV-2 infection. To date, few treatment options exist, although neutralizing antibodies against the spike glycoprotein have proven to be effecti
Autor:
Christine Toelzer, Imre Berger, Frederic Garzoni, Maia Kavanagh Williamson, Julien Capin, Oskar Staufer, Joachim P. Spatz, Andrew D. Davidson, Kapil Gupta, Deborah K. Shoemark, Daniel J. Fitzgerald, Adrian J. Mulholland, Rachel Milligan, Ufuk Borucu, Christiane Schaffitzel, K.N. Sathish Yadav
Publikováno v:
Science
Toelzer, C, Gupta, K, Yadav, S K N, Borucu, U, Davidson, A D, Kavanagh Williamson, M, Shoemark, D K, Garzoni, F, Staufer, O, Milligan, R, Capin, J, Mulholland, A J, Berger, I & Schaffitzel, C 2020, ' Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein ', Science, vol. 370, no. 6517, eabd3255 . https://doi.org/10.1126/science.abd3255
Science (New York, N.y.)
Toelzer, C, Gupta, K, Yadav, S K N, Borucu, U, Davidson, A D, Kavanagh Williamson, M, Shoemark, D K, Garzoni, F, Staufer, O, Milligan, R, Capin, J, Mulholland, A J, Berger, I & Schaffitzel, C 2020, ' Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein ', Science, vol. 370, no. 6517, eabd3255 . https://doi.org/10.1126/science.abd3255
Science (New York, N.y.)
Locking down the SARS-CoV-2 spike Many efforts to develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are focused on the spike (S) protein trimer that binds to the host receptor. Structures of trimeric S protein sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900a1a0a17e2248e7197013081ee0f35
https://pubmed.ncbi.nlm.nih.gov/32958580/
https://pubmed.ncbi.nlm.nih.gov/32958580/
Autor:
Srikrishna Subramanian, Gurmeet Kaur
Publikováno v:
Cell Cycle. 16:1918-1926
Threonine synthase (TS) catalyzes the terminal reaction in the biosynthetic pathway of threonine and requires pyridoxal phosphate as a cofactor. TSs share a common catalytic domain with other fold type II PALP dependent enzymes. TSs are broadly group
Publikováno v:
Journal of Biological Chemistry. 291:8978-8984
The genomes uncoupled 4 (GUN4) protein is a nuclear-encoded, chloroplast-localized, porphyrin-binding protein implicated in retrograde signaling between the chloroplast and nucleus, although its exact role in this process is still unclear. Functional
Publikováno v:
Cell Cycle
Despite extensive study, the mechanisms of cell fate choice upon p53 activation remain poorly understood. Using genome-wide shRNA screening, we recently identified the ATM kinase as synthetic lethal with Nutlin-3, an MDM2 inhibitor that leads to non-
Publikováno v:
Journal of Biological Chemistry. 289:10270-10275
Mature microRNAs (miRNAs), ∼ 22-nucleotide noncoding RNAs regulating target gene expression at the post-transcriptional level, have been recently shown to be transported into the nucleus where they modulate the biogenesis of other miRNAs or their o
Publikováno v:
Journal of Biological Chemistry. 289:5412-5416
Cancer cells are characterized by elevated levels of reactive oxygen species, which are produced mainly by the mitochondria. The dismutase SOD2 localizes in the matrix and is a major antioxidant. The activity of SOD2 is regulated by the deacetylase S
Publikováno v:
Journal of Biological Chemistry. 288:31350-31356
Mammalian sirtuins (SIRT1 through SIRT7) are members of a highly conserved family of NAD+-dependent protein deacetylases that function in metabolism, genome maintenance, and stress responses. Emerging evidence suggests that some sirtuins display subs
Autor:
John R. Konen, Kojo S.J. Elenitoba-Johnson, Henry L. Paulson, Kenneth Matthew Scaglione, Venkatesha Basrur, Sokol V. Todi, Naila S. Ashraf
Publikováno v:
Journal of Biological Chemistry. 288:18784-18788
Attachment of ubiquitin to substrate is typically thought to occur via formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and a lysine residue in the substrate. In vitro, Ube2w is nonreactive with free lysine yet read