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Autor:
Shengjie Xu, Nikhil Karmacharya, Gaoyuan Cao, Changjiang Guo, Andrew Gow, Reynold A. Panettieri, Joseph A. Jude
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(3)
Obesity can aggravate asthma by enhancing airway hyperresponsiveness (AHR) and attenuating response to treatment. However, the precise mechanisms linking obesity and asthma remain unknown. Human airway smooth muscle (HASM) cells exhibit amplified exc
Publikováno v:
Stem cells and development. 31(17-18)
Lineage-specific differentiation of human-induced pluripotent stem cells (hiPSCs) into cardiomyocytes (CMs) offers a patient-specific model to dissect development and disease pathogenesis in a dish. However, challenges exist with this model system, s
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:13-22
Endothelial colony-forming cells (ECFCs) are vascular resident and circulating endothelial cell subtypes with potent angiogenic capacity, a hierarchy of single-cell clonogenic potentials, and the ability to participate in
Publikováno v:
Biochemical and Biophysical Research Communications. 632:113-121
In this study, we aim to investigate the effect of metformin on cholesterol synthesis and efflux-related genes in chondrocytes during osteoarthritis (OA) and explore the underlying mechanisms. Primary chondrocytes were harvested from Wistar rat carti
Publikováno v:
Aging. 14:8914-8926
Skin aging caused by various endogenous and exogenous factors results in structural and functional changes to skin components. However, the role of senescent cells in skin aging has not been clarified. To elucidate the function of senescent cells in
Autor:
Fateme Azizi, Rasoul Ghasemi, Somayeh EbrahimiBarough, Maryam Ardalan, Mahmoudreza Hadjighassem
Publikováno v:
azizi, F, Ghasemi, R, EbrahimiBarough, S, Ardalan, M & Hadjighassem, M 2023, ' Effect of multifactorial therapeutic approach on axonal regeneration and cell viability in an in-vitro model of spinal-derived neural injury ', Cell and Tissue Banking, vol. 24, no. 2, pp. 471–484 . https://doi.org/10.1007/s10561-022-10047-z
The highly debilitated nature of spinal cord injuries (SCI) creates an inhibitory repair environment that limits the recovery rate and therefore single interventional treatment has been resulted in incomplete recovery. A multifactorial approach that
Autor:
Chen Qiu, Chuandong Wang, Xinghuai Sun, Jianjiang Xu, Jihong Wu, Rong Zhang, Gang Li, Kang Xue, Xiaoling Zhang, Shaohong Qian
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:5858-5871
As the main loading-bearing tissue of eye, sclera exerts an important role in the pathophysiology of glaucoma. Intraocular pressure (IOP) generates mechanical strain on sclera. Recent studies have demonstrated that sclera, especially the peripapillar
Autor:
Katherine N. MacDonald, Michael G. Hall, Sabine Ivison, Sanjiv Gandhi, Ramon I. Klein Geltink, James M. Piret, Megan K. Levings
Publikováno v:
Cytotherapy. 24:1121-1135
Given the promising results from phase 1/2 clinical trials of therapy involving regulatory T cells (Tregs), it is critical to develop Treg manufacturing methods that use well-defined reagents.Seeking to maximize expansion of human thymic Tregs activa
Autor:
Stefania Lenna, Ava Brozovich, Takashi Hirase, Francesca Paradiso, Bradley K. Weiner, Francesca Taraballi
Publikováno v:
Stem Cells and Development. 31:672-683
Due to their immunosuppressive potential and ability to differentiate into multiple musculoskeletal cell lineages, mesenchymal stromal cells (MSCs) became popular in clinical trials for the treatment of musculoskeletal disorders. The aim of this stud
Autor:
Shiwen Deng, Tong Lei, Hongyu Chen, Huiting Zheng, Zhuangzhuang Xiao, Shanglin Cai, Zhongci Hang, Weini Xiong, Yanqing Yu, Xiaoshuang Zhang, Yanjie Yang, Wangyu Bi, Hongwu Du
Publikováno v:
Cytotherapy. 24:1095-1104
Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabet