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Autor:
William E. Louch, Geir Christensen, Pimthanya Wanichawan, Hilde Jarstadmarken, Enno Klussmann, Marie C. Moutty, Ivar Sjaastad, Viacheslav O. Nikolaev, Cathrine R. Carlson, Per Kristian Lunde, Laetitia Pereira, Anna Bergan-Dahl, Ole M. Sejersted, Jan Magnus Aronsen, Marianne Lunde, Terje R Selnes Kolstad, Susanne Hille, Donald M. Bers, Bjørn Dalhus, Hariharan Subramanian, Oliver Müller, Xin Shen
Publikováno v:
Circulation research, vol 130, iss 1
Background: The sarcoplasmic reticulum (SR) Ca 2+ -ATPase 2 (SERCA2) mediates Ca 2+ reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) mediates Ca 2+ release from SR and triggers contraction. Ca 2+ /C
Publikováno v:
Journal of Leukocyte Biology. 111:1185-1197
Macrophages are widely distributed in a variety of tissues, and the different state of macrophages polarization is closely related to the occurrence, development, and prognosis of inflammation, including periodontitis, a chronic inflammatory disease
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific Reports
Scientific Reports
The epidermal basement membrane deteriorates with aging. We previously reported that basement membrane reconstruction not only serves to maintain epidermal stem/progenitor cells in the epidermis, but also increases collagen fibers in the papillary de
Autor:
Justyna Piotrowska, Fiona R. Passanha, David B. Gomes, Matthew B. Baker, Lorenzo Moroni, Vanessa L.S. LaPointe
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine, 16(1), 14-25. Wiley
There is increasing evidence that cells cultured in three-dimensional (3D) settings have superior performance compared to their traditional counterparts in monolayers. This has been attributed to cell-cell and cell-extracellular matrix interactions t
Autor:
Kaveena Autar, Xiufang Guo, John W. Rumsey, Christopher J. Long, Nesar Akanda, Max Jackson, Narasimhan S. Narasimhan, Julbert Caneus, Dave Morgan, James J. Hickman
Publikováno v:
Stem Cell Reports
Summary The maturation and functional characteristics of human induced pluripotent stem cell (hiPSC)-cortical neurons has not been fully documented. This study developed a phenotypic model of hiPSC-derived cortical neurons, characterized their matura
Autor:
Nguyen, Liem Thanh, Tran, Nghia Trung, Than, Uyen Thi Trang, Nguyen, Minh Quang, Tran, Anh Minh, Do, Phuong Thi Xuan, Chu, Thao Thi, Nguyen, Tu Dac, Bui, Anh Viet, Ngo, Tien Anh, Hoang, Van Thanh, Hoang, Nhung Thi My
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2022)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Although umbilical cord blood (UCB) is identified as a source of mesenchymal stem cells (MSCs) with various advantages, the success in cell isolation is volatile. Therefore, it is necessary to optimize methods of cord blood-derived MSC (UC
Autor:
Aman George, Ruchi Sharma, Tyler Pfister, Mones Abu-Asab, Nathan Hotaling, Devika Bose, Charles DeYoung, Justin Chang, David R. Adams, Tiziana Cogliati, Kapil Bharti, Brian P. Brooks
Publikováno v:
Stem Cell Reports
Summary Oculocutaneous albinism (OCA) encompasses a set of autosomal recessive genetic conditions that affect pigmentation in the eye, skin, and hair. OCA patients display reduced best-corrected visual acuity, reduced to absent ocular pigmentation, a
Autor:
Shiori, Awa, Genjiro, Suzuki, Masami, Masuda-Suzukake, Takashi, Nonaka, Minoru, Saito, Masato, Hasegawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports
Scientific Reports
Accumulation of phosphorylated α-synuclein aggregates has been implicated in several diseases, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and is thought to spread in a prion-like manner. Elucidating the mechanisms of prion
Autor:
Lai Ling Tsang, Gang Li, Fuyuan Yang, Ye Chun Ruan, Zhihui Weng, Jiawei Huang, Tobias D Merson, Zeyuan Ji, Jiacheng Lin, Xiaohua Jiang, Chao Wan, Kin Pong U
Publikováno v:
Theranostics
Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is emerging as a promising treatment avenue for HIE. However, despite its enormous potential,
Autor:
Oscar Palomares, Alba Angelina, Beate Rückert, Mar Martín-Fontecha, Mario Pérez-Diego, Cezmi A. Akdis, Jacobo López-Abente, Ivan Nombela, Mübeccel Akdis
Publikováno v:
Mucosal Immunology
E-Prints Complutense. Archivo Institucional de la UCM
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E-Prints Complutense. Archivo Institucional de la UCM
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The generation of functional regulatory T cells (Tregs) is essential to keep tissue homeostasis and restore healthy immune responses in many biological and inflammatory contexts. Cannabinoids have been pointed out as potential therapeutic tools for s