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Autor:
Marie Malissen, Zhuangzhuang Liu, Gu Yanrong, Le He, Rui Fu, Huang Rong, Liaoxun Lu, Lichen Zhang, Yinming Liang, Guo Guo
Publikováno v:
Journal of visualized experiments : JoVE
Journal of visualized experiments : JoVE, 2021, 177, ⟨10.3791/62328⟩
Journal of visualized experiments : JoVE, 2021, 177, ⟨10.3791/62328⟩
Functional genomics studies of the immune system require genetic manipulations that involve both deletion of target genes and addition of elements to proteins of interest. Identification of gene functions in cell line models is important for gene dis
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10972, p 10972 (2021)
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10972, p 10972 (2021)
MicroRNAs are known to play a critical role in skeletal myogenesis and maintenance, and cofilin-2 (CFL2) is necessary for actin cytoskeleton dynamics and myogenic differentiation. Nonetheless, target molecules and the modes of action of miRNAs, espec
Autor:
Simon Mead, Simone Hornemann, Marc Emmenegger, Elke Schaper, Kevin Maggi, Peter Heutink, Jiang-An Yin, Anna Spinelli, Ashutosh Dhingra, Daniel Heinzer, Berre Doğançay, Merve Avar, Daniel Patrick Pease, Adriano Aguzzi, Andra Chincisan
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS pathogens 17(10), e1010013 (2021). doi:10.1371/journal.ppat.1010013
PLoS Pathogens, Vol 17, Iss 10, p e1010013 (2021)
PLoS Pathogens
PLoS pathogens 17(10), e1010013 (2021). doi:10.1371/journal.ppat.1010013
PLoS Pathogens, Vol 17, Iss 10, p e1010013 (2021)
PLoS Pathogens
The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against hu
Autor:
Shaoqun Shu, Jiefu Zhu, Anqun Chen, Hui Wang, Wenwen Wu, Juan Cai, Zhiwen Liu, Danyi Yang, Chengyuan Tang, Zheng Dong
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in chronic kidney injury and renal fibrosis. However, the relationship and regulatory mechanisms between ER stress and autophagy under this condition remain largely unknown. In
Autor:
Hong-Mei Li, Michael N. Teng, MengJie Hu, Lora M. Starrs, John Mills, David A. Jans, Kim C. Tran, Reena Ghildyal
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2786, p 2786 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2786, p 2786 (2021)
The morbidity and mortality caused by the globally prevalent human respiratory pathogen respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously demonstrated that the RSV matrix (M) protein shuttles, in signal-dependen
Publikováno v:
Pediatric pulmonologyREFERENCES. 57(1)
Objective Studies have shown that the expression of CCCTC-binding factor (CTCF) is significantly upregulated in the airway epithelial cells of asthmatic patients, suggesting that CTCF may play an important role in the progression of asthma. Material/
Autor:
Jingyi Zeng, Xiaorong Bao
Publikováno v:
Folia histochemica et cytobiologica. 59(4)
Introduction The progression of diabetic kidney disease (DKD) is closely related to renal tubular epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis. Tanshinone IIA (TSIIA), extracted from a traditional Chinese medicine named
Autor:
Jesper Sohlmer, Nevin Witman, William E. Louch, Eduarde Rohner, Erwin De Genst, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Molecular Medicine
Molecular Medicine
BackgroundThe human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous studies have
Autor:
Assirbad Behura, Ramandeep Singh, Amit Mishra, Debraj Manna, Lincoln Naik, Ashish Kumar, Rohan Dhiman, Salina Patel, Abtar Mishra, Mousumi Das
Publikováno v:
International immunopharmacology. 101
The weaponry possessed by Mycobacterium tuberculosis (M. tb) in the form of immunodominant antigens hijack the host immune system to give a survival advantage to this intracellular fiend, but the mechanism of this control is not entirely known. Since
Autor:
Felipe Guapo, Niall Barron, Jonathan Bones, Nicholas Donohue, Lisa Strasser, Alana Rainbow-Fletcher, Stefano Boi
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11499, p 11499 (2021)
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11499, p 11499 (2021)
Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV manufacturing is still challenging, with production yields being lim