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Autor:
Noopur Raje, Chukwuamaka Onyewadume, Cristina Panaroni, Ka Tat Siu, Keertik Fulzele, Tomoaki Mori, Allison Maebius
Publikováno v:
Blood
Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein multiple myeloma (MM) originates and resides. However, the nature of the interaction between MM cells and adipocytes remains unclear. Cancer-associated adipocytes suppor
Autor:
Danforth A. Newton, Rita M. Ryan, Manjeet K. Paintlia, Demetri D. Spyropoulos, Alan H. Jobe, Matthew W. Kemp, John E. Baatz
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased postnatally.
Publikováno v:
Biochemical and Biophysical Research Communications. 580:1-6
Sphingosine kinase 2 (SphK2) inhibitors are developed for tumor therapy as considering its anti-tumor effect. Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases thera
Autor:
Jin-Liang Yue, Shu-Feng Zheng
Publikováno v:
Journal of Cellular and Molecular Medicine
MALAT1, which is disorderly expressed in the growth, invasion, migration and cancer cell apoptosis, was shown to be associated with normal‐tension glaucoma (NTG), a type of optic neuropathy. The haplotype in MALAT1 affects its expression and is cor
Autor:
Yu-An Zhang, Johanne Pastor, Joshuah M Gagan, Orson W. Moe, Jianning Zhang, Connie C.W. Hsia, Khoa Cao, Taylor L. Davidson
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of
Publikováno v:
Journal of Cellular and Molecular Medicine
This study aimed to explore the possibility of miR‐423‐5p modified adipose‐derived stem cell (ADSCs) therapy on streptozotocin (STZ)‐induced diabetes mellitus erectile dysfunction (DMED) rats. MiR‐423‐5p was knocked down in ADSCs. ADSCs,
Autor:
Kiyohito Sasa, Atsushi Yamada, Takahiro Funatsu, Karin Nagata, Tomomi Sugiyama, Masumi Kugino, Masakazu Nitta, Tomokazu Hasegawa, Ryutaro Kamijo, Kentaro Yoshimura, Mitsuhiro Kinoshita, Takeyoshi Asakawa
Publikováno v:
Human Cell
Down’s syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To examine involvement of the disease with periodontal disease development, we established immortalized pe
Publikováno v:
Human Cell. 34:1697-1708
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)-based therapy is currently considered to be an effective treatment for NAFLD. The present study aimed to determ
Publikováno v:
Biology of Reproduction. 105:1355-1364
Bisphenol A (BPA) is one of the most investigated compound as a suspected endocrine disrupting chemical. It has been found at nM concentrations in the maternal serum, cord serum, and amniotic fluid and also permeates placental tissues. Attempts are b
Publikováno v:
Clinical and Experimental Nephrology. 25:1182-1192
Tubular injury plays a crucial role in the pathogenesis of diabetic nephropathy (DN). It is well known that many microRNAs (miRNAs) exert crucial effects on tubular injury. This study intends to explore the effect of miR-142-3p on the apoptosis and o