Zobrazeno 1 - 10
of 7 999
pro vyhledávání: ''
Autor:
Alicia Roig-Merino, Manuela Urban, Matthias Bozza, Julia D. Peterson, Louise Bullen, Marleen Büchler-Schäff, Sina Stäble, Franciscus van der Hoeven, Karin Müller-Decker, Tristan R. McKay, Michael D. Milsom, Richard P. Harbottle
Publikováno v:
Stem Cell Reports
Summary The genetic modification of stem cells (SCs) is typically achieved using integrating vectors, whose potential integrative genotoxicity and propensity for epigenetic silencing during differentiation limit their application. The genetic modific
Autor:
Yaoyong Li, Samantha Carrera, Andrew D. Sharrocks, Karol Nowicki-Osuch, Shen Hsi Yang, Syed Murtuza Baker, David G. Spiller, Amanda O'Donnell
Publikováno v:
Nucleic Acids Research
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
High levels of histone acetylation are associated with the regulatory elements of active genes, suggesting a link between acetylation and gene activation. We revisited this model, in the context of EGF-inducible gene expression and found that rather
Autor:
Masa-Aki Ikeda, Khandakar A.S.M. Saadat, Zekiye Altan, Cuneyd Parlayan, Kaifee Arman, Yunus Sahin
Publikováno v:
Biochemical and Biophysical Research Communications. 585:89-95
Osteosarcoma (OS) is the most common primary malignant bone tumor which has unclear pathobiology. Hence, enlightening the exact molecular mechanism underlying osteosarcoma progression is crucial for developing new treatment strategies. One member of
Publikováno v:
Biochemical and Biophysical Research Communications. 582:8-15
Gap junction beta 1 (GJB1) is the pathogenic gene of X-linked Charcot-Marie-Tooth type 1 (CMTX1), a rare hereditary sensorimotor neuropathy. However, different mutations of GJB1 result in heterogeneous clinical manifestations with only some mutations
Autor:
Zhao Zhang, Man Jiang, Moubin Lin, Jiayin Peng, Hailong Wu, Yiao Jiang, Liya Ma, Dong Gao, Yun Zhao, Jiawen Song, Jia Wang, Juan He, Yuang Wang
Publikováno v:
Nat Metab
The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid metabolism and related diseases. However, the underlying mechanisms are poorly understood. Here, we show that the Hh signalling pathway induces a previously undefine
Publikováno v:
Stem Cell Reports
Summary Tbx3 has been identified as a regulator of liver development in the mouse, but its function in human liver development remains unknown. TBX3 mutant human pluripotent stem cell (PSC) lines were generated using CRISPR/Cas9 genome editing. TBX3
Publikováno v:
Molecular Therapy. 29:3274-3292
With the development of CRISPR-Cas9-mediated gene-editing technologies, correction of disease-causing mutations has become possible. However, current gene-correction strategies preclude mutation repair in post-mitotic cells of human tissues, and a un
Autor:
Young Jae Lee, Jung-Hoon Pyun, Na-Jung Kim, Jong-Sun Kang, Kang-Hoon Lee, YeonSung Son, Jinyoung Park, Eun-Hye Moon, Je-Yoel Cho, A-Reum Nam
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The roles of long non-coding RNA (LncRNA) have been highlighted in various development processes including congenital heart defects (CHD). Here, we characterized the molecular function of LncRNA, Moshe (1010001N08ik-203), one of the Gata6 antisense t
Autor:
Kwang Won Jeong
Publikováno v:
Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 115-1631
Current Issues in Molecular Biology, Vol 43, Iss 115, Pp 1623-1631 (2021)
Volume 43
Issue 3
Pages 115-1631
Current Issues in Molecular Biology, Vol 43, Iss 115, Pp 1623-1631 (2021)
Aryl hydrocarbon receptors (AHRs), a class of ligand-dependent nuclear receptors that regulate cellular responses by inducing the expression of various target genes in response to external signals, are implicated in maintaining retinal tissue homeost
Publikováno v:
Molecular Biology Reports
Carson, J, Robinson, M, Ramm, G A & Gobert, G 2021, ' RNA sequencing of LX-2 cells treated with TGF-β1 identifies genes associated with hepatic stellate cell activation ', Molecular Biology Reports . https://doi.org/10.1007/s11033-021-06774-3
Carson, J, Robinson, M, Ramm, G A & Gobert, G 2021, ' RNA sequencing of LX-2 cells treated with TGF-β1 identifies genes associated with hepatic stellate cell activation ', Molecular Biology Reports . https://doi.org/10.1007/s11033-021-06774-3
Background Hepatic stellate cells (HSCs) are liver-resident myofibroblast precursors responsible for the production of collagen and maintenance of the hepatic extracellular matrix (ECM). As such, they are generally associated with fibrotic liver dise