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Publikováno v:
Osteoarthritis Cartilage
Summary Objectives Recent studies have shown that tRNA-derived RNA fragments (tRFs) are novel regulators of post-transcriptional gene expression. However, the expression profiles and their role in post-transcriptional gene regulation in chondrocytes
Autor:
Xiao-yuan Huang, Jizhang Zeng, Licheng Ren, Le Guo, Xu Huang, Mengting Duan, Zaiwen Guo, Pihong Zhang, Bimei Jiang, Wenchang Yu, Pengfei Liang, Minghua Zhang
Publikováno v:
Burns. 46:1128-1135
Objective Thermal injury repair is a complex process during which maintaining the proliferation of human dermis fibroblasts (HDFs) and synthesis of extracellular matrix (ECM) plays a critical role. In the present study, we analyzed potential molecula
Publikováno v:
ACS Synthetic Biology
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
An important feature of synthetic biological circuits is their response to physicochemical signals, which enables the external control of cellular processes. Calcium-dependent regulation is an attractive approach for achieving such control, as divers
Autor:
Je Young Shin, Kyung Won Choi, Ki Yoon Kim, Yoon-Ho Hong, Somyung Lee, Jin Young Kim, Jung-Joon Sung, Wooseok Im, Yu Ri Kim, Manho Kim, Mijung Lee, Jong Il Kim
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-21 (2020)
Translational Neurodegeneration
Translational Neurodegeneration
Background MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important role in ALS; however, the pathog
Publikováno v:
International Journal of Molecular Medicine
Human bone marrow‑derived mesenchymal stem cells (HBMSCs) have the potential of multidirectional differentiation and self‑renewal, which is important for the formation of human bone. It has been reported that long non‑coding RNAs (lncRNAs) serv
Autor:
Beiyun Zhou, Zea Borok, Crystal N. Marconett, Megan E. Rieger, Kusum Pandit, Ite A. Offringa, Alessandra Castaldi, Masafumi Horie, Mitsuhiro Sunohara, Mickael Dubourd
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 cells for normal maintenance and restoration of epithelial int
Publikováno v:
Biochemical and Biophysical Research Communications. 527:974-978
Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors essential for cytokine signaling. Our previous study showed that interleukin-3 (IL-3) induced STAT5 translocation to mitochondria and bindin
Autor:
Reynald Thinard, Sezgi Arpag, Claude Nicolau, Melanie Chevalier, Loree C. Heller, Richard Heller, Yu Jing, Ruth Greferath
Publikováno v:
Journal of Cellular and Molecular Medicine
In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood‐brain barrier (BBB) breakdown. After intravenous or intra‐arterial injection
Autor:
Xiaolei Ma, Christopher Bower-Lepts, Jeremy C. Mottram, Frantisek Supek, Eric Fang, Elmarie Myburgh, Marcel Kaiser, Manuel Saldivia, Michael P. Barrett, Daniel Paape, Thierry T. Diagana, Yen Liang Chen, Suresh B Lakhsminarayana, Jan Jiricek, Ryan Ritchie, Elizabeth Ornelas, Richard McCulloch, Srinivasa P. S. Rao, Hazel X. Y. Koh, Debjani Patra, Juliana B.T. Carnielli, Sarah Williams, Elaine Brown
Publikováno v:
Nature microbiology
The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis. In Trypanosoma brucei the proteins that make up the kinetochore are highly
Autor:
Niraj Kumar, Suchitra D. Gopinath, Yashwant Kumar, Ashok Kumar, Jayesh Kumar Sevak, Sonu Kumar
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Skeletal muscle constitutes more than 30% of total body mass using substrates such as glycogen, glucose, free fatty acids, and creatinine phosphate to generate energy. Consequently, multinucleated myofibers and resident mononucleated stem cells (sate