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Autor:
Young Jae Lee, Jung-Hoon Pyun, Na-Jung Kim, Jong-Sun Kang, Kang-Hoon Lee, YeonSung Son, Jinyoung Park, Eun-Hye Moon, Je-Yoel Cho, A-Reum Nam
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The roles of long non-coding RNA (LncRNA) have been highlighted in various development processes including congenital heart defects (CHD). Here, we characterized the molecular function of LncRNA, Moshe (1010001N08ik-203), one of the Gata6 antisense t
Autor:
Manman He, Jiabin Yang, Fang Wang, Hua-Lu Zhao, Siqi Liu, Lingjie Xu, Hongmei Zhao, Shuan Rao, Xiaoshuang Wang, Jing Wang, Yanmin Si, Yue Ren, Yue Huo, Weiqian Li, Yuehong Guo, Yanni Ma, Jia Yu
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Genome Biology
Genome Biology
BackgroundCellular RNA-binding proteins (RBPs) have multiple roles in post-transcriptional control, and some are shown to bind DNA. However, the global localization and the general chromatin-binding ability of RBPs are not well-characterized and rema
Autor:
Shaina N. Porter, Phillip A. Doerfler, Merlin Crossley, Mitchell J. Weiss, Shondra M. Pruett-Miller, Henry W Bell, Yong Cheng, Lance E. Palmer, Ruopeng Feng, Yichao Li
Publikováno v:
Nature genetics
Hereditary persistence of fetal hemoglobin (HPFH) ameliorates β-hemoglobinopathies by inhibiting the developmental switch from γ-globin (HBG1/HBG2) to β-globin (HBB) gene expression. Some forms of HPFH are associated with γ-globin promoter varian
Autor:
Myriam Gorospe, Jennifer L. Martindale, Ming-Wen Chang, Dimitrios Tsitsipatis, Jen-Hao Yang, Supriyo De, Xiaoling Yang, Rachel Munk, Poonam R. Pandey, Kotb Abdelmohsen
Publikováno v:
Nucleic Acids Res
Long noncoding (lnc)RNAs potently regulate gene expression programs in physiology and disease. Here, we describe a key function for lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate into myotubes during muscle development and
Autor:
Jie Liu, Mohammad Ishaque Ali, Guoquan Liu, Wei Gu, Shuguang Huang, Linrui Li, Lexing Li, Bingyu Wang, Lun Yao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Endogenous miR22 is associated with a diverse range of biological processes through post-translational modification of gene expression and its deregulation results in various diseases including cancer. Its expression is usually tissue or cell-specifi
Autor:
Zachary Kraus, Pei-Jyun Liao, Jessica Dement-Brown, Ilya Mazo, Mate Tolnay, Frederick Mills, Sean P. Fitzsimmons, Huifang Li
Publikováno v:
International Immunology. 32:755-770
Atypical memory B cells accumulate in chronic infections and autoimmune conditions, and commonly express FCRL4 and FCRL5, respective IgA and IgG receptors. We characterized memory cells from tonsils on the basis of both FCRL4 and FCRL5 expression, de
Publikováno v:
ACS Synthetic Biology
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
An important feature of synthetic biological circuits is their response to physicochemical signals, which enables the external control of cellular processes. Calcium-dependent regulation is an attractive approach for achieving such control, as divers
Autor:
Je Young Shin, Kyung Won Choi, Ki Yoon Kim, Yoon-Ho Hong, Somyung Lee, Jin Young Kim, Jung-Joon Sung, Wooseok Im, Yu Ri Kim, Manho Kim, Mijung Lee, Jong Il Kim
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-21 (2020)
Translational Neurodegeneration
Translational Neurodegeneration
Background MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases. Overexpressed miRNAs play an important role in ALS; however, the pathog
Publikováno v:
Biochemical and Biophysical Research Communications. 527:974-978
Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors essential for cytokine signaling. Our previous study showed that interleukin-3 (IL-3) induced STAT5 translocation to mitochondria and bindin
Autor:
Lena Al-Harthi, Jennillee Wallace, Ethan M. Ritz, KaReisha F. Robinson, Srinivas D. Narasipura
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-14 (2020)
Cell Communication and Signaling : CCS
Cell Communication and Signaling : CCS
Background The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF family of transcription factor