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Autor:
Kiyohito Sasa, Atsushi Yamada, Takahiro Funatsu, Karin Nagata, Tomomi Sugiyama, Masumi Kugino, Masakazu Nitta, Tomokazu Hasegawa, Ryutaro Kamijo, Kentaro Yoshimura, Mitsuhiro Kinoshita, Takeyoshi Asakawa
Publikováno v:
Human Cell
Down’s syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To examine involvement of the disease with periodontal disease development, we established immortalized pe
Publikováno v:
Human Cell. 34:1697-1708
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)-based therapy is currently considered to be an effective treatment for NAFLD. The present study aimed to determ
Publikováno v:
Clinical and Experimental Nephrology. 25:1182-1192
Tubular injury plays a crucial role in the pathogenesis of diabetic nephropathy (DN). It is well known that many microRNAs (miRNAs) exert crucial effects on tubular injury. This study intends to explore the effect of miR-142-3p on the apoptosis and o
Publikováno v:
Aging (Albany NY)
Ribonucleotide reductase subunit M2 may play a role as a potential prognostic biomarker in several cancers. In this study, we evaluated whether RRM2 gene expression is associated with the prognosis of patients with lung adenocarcinoma (LUAD) using pu
Autor:
Michiko Yanagisawa, Kazuhiko Namekata, Tomomi Aida, Sayaka Katou, Takuya Takeda, Takayuki Harada, Nobuo Fuse, null the Glaucoma Gene Research Group, Kohichi Tanaka
Publikováno v:
Biochemical and Biophysical Research Communications. 529:943-949
Glaucoma is one of the leading causes of blindness characterized by progressive loss of retinal ganglion cells (RGCs) and their axons. We reported that glutamate/aspartate transporter (GLAST) knockout mice showed progressive RGC loss and optic nerve
Autor:
Bing Li, Guangrong Yu, Youguang Zhao, Jiang Xia, Tao Yu, Yuan Xiong, Wenbao He, Hui Zhu, Alex Kang, Haichao Zhou, Yunfeng Yang, Zihua Li, Xiaomeng You
Publikováno v:
Aging (Albany NY)
Osteoporosis is a metabolic disease affecting 40% of postmenopausal women. It is characterized by decreased bone mass per unit volume and increased risk of fracture. We investigated the molecular mechanism underlying osteoporosis by identifying the g
Publikováno v:
Metabolism. 98:95-103
Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD). Vitamin D receptor (VDR) belongs to the nuclear receptor superfamily and exerts a renoprotective effect through inhibiting fibrosis. Microtubule-associated protein 1 light
Autor:
Ryogo Katada, Ikuko Takakura, Kotaro Azuma, Tatsuo Shirota, Kenji Mishima, Takaaki Kamatani, Junichi Tanaka, Keiko Aota, Koki Takamatsu, Satoshi Inoue
Publikováno v:
Experimental cell research. 409(1)
Although stem cell aging leads to a decline in tissue homeostasis and regenerative capacity, it remains unclear whether salivary gland stem cell function changes during this process. However, the salivary glands are gradually replaced by connective t
Autor:
Suxin Luo, Yong Xia, Minghao Luo, Yongzheng Guo, Zhe Cheng, An He, Chang Li, Longxiang Huang, Xiyang Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
O-GlcNAcylation, an energy-sensitive posttranslational modification, can regulate the activity of endothelial nitric oxide synthase (eNOS). Previous studies found that Thr866 is the key site for low-glucose-mediated regulation of eNOS O-GlcNAc. Howev
Autor:
Yu-Qin Wang, Xiao-Yan Duan, Jian-Gao Fan, Xiao-Lin Liu, Hai-Xia Cao, Baocan Wang, Ruixian Huang
Publikováno v:
Biochemical and Biophysical Research Communications. 508:1252-1258
Recent studies have reported elevated expression of miR-181a in patients with non-alcoholic fatty liver disease (NAFLD), suggesting that it may play an important role in liver lipid metabolism and insulin resistance. We aimed to investigate the effec