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Publikováno v:
Brazilian Journal of Biology, Vol 84 (2021)
Brazilian Journal of Biology, Volume: 84, Article number: e250151, Published: 22 NOV 2021
Brazilian Journal of Biology v.84 2024
Brazilian Journal of Biology
Instituto Internacional de Ecologia (IIE)
instacron:IIE
Brazilian Journal of Biology, Volume: 84, Article number: e250151, Published: 22 NOV 2021
Brazilian Journal of Biology v.84 2024
Brazilian Journal of Biology
Instituto Internacional de Ecologia (IIE)
instacron:IIE
Mammals have a limited capacity to regenerate their tissues and organs. One of the mechanisms associated with natural regeneration is dedifferentiation. Several small molecules such as vitamin C and growth factors could improve reprogramming efficien
Autor:
Michael R. Hicks, April D. Pyle
Publikováno v:
Trends in cell biology, vol 33, iss 2
Stem cell niches are composed of dynamic microenvironments that support stem cells over a lifetime. The emerging niche is distinct from the adult because its main role is to support the progenitors that build organ systems in development. Emerging ni
Publikováno v:
Stem cells and development. 31(17-18)
Lineage-specific differentiation of human-induced pluripotent stem cells (hiPSCs) into cardiomyocytes (CMs) offers a patient-specific model to dissect development and disease pathogenesis in a dish. However, challenges exist with this model system, s
Autor:
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Cytotherapy. 25:59-67
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to ter
Publikováno v:
Seminars in Cell & Developmental Biology. 133:123-134
Stem cells can generate a diversity of cell types during development, regeneration and adult tissue homeostasis. Differentiation changes not only the cell fate in terms of gene expression but also the physical properties and functions of cells, e.g.
Publikováno v:
Aging. 14:9860-9876
Muscle mass decreases with aging, while the C-C motif chemokine ligand 2 (CCL2) increases with aging; in this context, CCL2 can be considered a potential aging-promoting factor. Thus, CCL2 knockout mice are expected to exhibit anti-aging effects incl
Autor:
Alasdair Cameron, Griffen Wakelin, Nicholas Gaulton, Laura V. Young, Scott Wotherspoon, Nathan Hodson, Matthew J. Lees, Daniel R. Moore, Adam P. Johnston
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1586-C1600
Skeletal muscle repair and maintenance are directly and indirectly supported by interstitial cell populations such as vascular cells and fibro-adipogenic progenitors (FAPs), a subset of which express Twist2 and possess direct myogenic potential. Furt
Autor:
Naoaki Watanabe, Yu Fujita, Jun Nakayama, Yutaro Mori, Tsukasa Kadota, Yusuke Hayashi, Iwao Shimomura, Takashi Ohtsuka, Koji Okamoto, Jun Araya, Kazuyoshi Kuwano, Yusuke Yamamoto
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:708-719
Phenotypic alterations in the lung epithelium have been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, but the precise mechanisms orchestrating this persistent inflammatory process remain unknown because of the comple
Autor:
Zahra Amidzadeh, Setayesh Yasami‐Khiabani, Hamzeh Rahimi, Shahin Bonakdar, Davoud Shams, Mahdi Habibi‐Anbouhi, Majid Golkar, Mohammad Ali Shokrgozar
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:5929-5942
Different growth factors can regulate stem cell differentiation. We used keratinocyte growth factor (KGF) to direct adipose-derived stem cells (ASCs) differentiation into keratinocytes. To enhance KGF bioavailability, we targeted KGF for collagen by
Publikováno v:
Differentiation. 128:67-82
Macrophages derived from human monocytic leukemia THP-1 cell line are often used as the alternative of human primary macrophage. However, the polarization method of THP-1 to macrophages varies between different laboratories, which may unknowingly aff