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Publikováno v:
Stem Cell Reports. 17:2167-2171
In a recently published study, Xu et al. used two surface markers, CLSTN2 and PTPRO, to generate highly purified donor dopaminergic neurons and achieved stable and predictable therapeutic outcomes by transplantation into the brain of PD animal models
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 58:817-829
Human taste cells are a heterogeneous population of specialized epithelial cells that are constantly generated from progenitor taste cells. Type I and type III taste cells express some neural markers, and studies have reported that direct innervation
Autor:
Zoe Tasma, Weilin Hou, Tanvi Damani, Kathleen Seddon, Matthew Kang, Yi Ge, David Hanlon, Fiona Hollinshead, Colin L Hisey, Lawrence W Chamley
Publikováno v:
Reproduction. 164:143-154
In brief Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have shown promise as off-the-shelf therapeutics; however, producing them in sufficient quantities can be challenging. In this study, MSCs were isolated from preimplantation
Autor:
Henrik Ahlenius
Publikováno v:
Cellular Reprogramming. 24:205-211
Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell
Publikováno v:
Cell Biology International. 46:2220-2231
Diabetic osteoporosis (DOP) is a disorder of bone metabolism induced by multiple mechanisms. Previous studies have revealed that microRNAs (miRNAs) play crucial roles in bone metabolism. MiRNA-144-5p has been proven to participate in the regulation o
Publikováno v:
Cell Biology International. 46:2118-2131
The cellular heterogeneity and genetic features of stemness of adipose-derived stromal cells (ADSCs) remain unclear. Using single-cell RNA sequencing (scRNA-seq), we investigated the genomic features of the stemness gene in ADSCs with genetic variabi
Autor:
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Dave Horsfall, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier
Publikováno v:
Nature Cell Biology. 24:1487-1498
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances have been hampered by the lack of knowledge concerning human hepatic development. Here, we addressed this limitati
Autor:
Ying‐Ying Teng, Ming‐Li Zou, Xiao‐Jin Zhou, Jun‐Jie Wu, Si‐Yu Liu, Zheng‐Dong Yuan, Yuan Jia, Kai‐Wen Zhang, Xia Li, Jun‐Xing Ye, Feng‐Lai Yuan
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:5113-5121
Disturbances or defects in the process of wound repair can disrupt the delicate balance of cells and molecules necessary for complete wound healing, thus leading to chronic wounds or fibrotic scars. Myofibroblasts are one of the most important cells
Autor:
Belinda J. Hernandez, Margo P. Cain, Anne M. Lynch, Jose R. Flores, Michael J. Tuvim, Burton F. Dickey, Jichao Chen
Publikováno v:
Am J Respir Cell Mol Biol
The lung epithelium forms the first barrier against respiratory pathogens and noxious chemicals; however, little is known about how more than 90% of this barrier, made of AT1 (alveolar type 1) cells, responds to injury. Using the Sendai virus to mode
Autor:
Clark A. Bonham, Dharshan Sivaraj, Michael T. Longaker, Jagannath Padmanabhan, Kellen Chen, Dominic Henn, Derrick C. Wan, Michael Januszyk, Artem A. Trotsyuk, Geoffrey C. Gurtner, Michelle Griffin, Hudson Choi Kussie
Publikováno v:
Advances in Wound Care. 11:466-478
Objective: After injury, humans and other mammals heal by forming fibrotic scar tissue with diminished function, and this healing process involves the dynamic interplay between resident cells withi...