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Autor:
Brandon T. Wesley, Alexander D. B. Ross, Daniele Muraro, Zhichao Miao, Sarah Saxton, Rute A. Tomaz, Carola M. Morell, Katherine Ridley, Ekaterini D. Zacharis, Sandra Petrus-Reurer, Judith Kraiczy, Krishnaa T. Mahbubani, Stephanie Brown, Jose Garcia-Bernardo, Clara Alsinet, Daniel Gaffney, Dave Horsfall, Olivia C. Tysoe, Rachel A. Botting, Emily Stephenson, Dorin-Mirel Popescu, Sonya MacParland, Gary Bader, Ian D. McGilvray, Daniel Ortmann, Fotios Sampaziotis, Kourosh Saeb-Parsy, Muzlifah Haniffa, Kelly R. Stevens, Matthias Zilbauer, Sarah A. Teichmann, Ludovic Vallier
Publikováno v:
Nature Cell Biology. 24:1487-1498
The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances have been hampered by the lack of knowledge concerning human hepatic development. Here, we addressed this limitati
Publikováno v:
Biochemical and Biophysical Research Communications. 619:27-33
Transcription factors are key determinants of lineage commitment during mammalian development. However, the function and molecular mechanism for the transcription factors in the formation of three primary germ layers during human embryonic developmen
Autor:
Ava Keyvani Chahi, Muluken S. Belew, Joshua Xu, He Tian Tony Chen, Stefan Rentas, Veronique Voisin, Gabriela Krivdova, Eric Lechman, Sajid A. Marhon, Daniel D. De Carvalho, John E. Dick, Gary D. Bader, Kristin J. Hope
Publikováno v:
Blood. 140:992-1008
Hematopoietic stem cell (HSC) dormancy is understood as supportive of HSC function and its long-term integrity. Although regulation of stress responses incurred as a result of HSC activation is recognized as important in maintaining stem cell functio
Publikováno v:
Current Eye Research. 47:1300-1311
Background: Phase I/II clinical trials using fetal retinal pigment epithelium (fRPE), human embryonic stem cell (hESC)-derived RPE, or human induced pluripotent stem cell (hiPSC)-derived RPE as potential sources of materials for cell-based therapy to
Publikováno v:
Biochemical Journal. 479:1375-1392
The TP63 is an indispensable transcription factor for development and homeostasis of epithelia and its derived glandular tissue. It is also involved in female germline cell quality control, muscle and thymus development. It is expressed as multiple i
Publikováno v:
Stem Cells and Development. 31:269-277
Human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells (hiPSCs), provide promising sources for regenerative therapy, disease modeling, and drug screening. Relevant efforts have been investe
Autor:
Aurelio Balsalobre, Jacques Drouin
Publikováno v:
Nature Reviews Molecular Cell Biology. 23:449-464
Pioneer factors are transcription factors with the unique ability to initiate opening of closed chromatin. The stability of cell identity relies on robust mechanisms that maintain the epigenome and chromatin accessibility to transcription factors. Pi
Autor:
Riping, Xiao, Kawai, Lei, Hioha, Kuok, Wende, Deng, Yuxin, Zhuang, Yanqing, Tang, Zhengyang, Guo, Hongyan, Qin, Li-Ping, Bai, Ting, Li
Publikováno v:
Journal of Leukocyte Biology. 112:835-843
Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver and released into the intestine to facilitate the digestion and absorption of lipids. BAs are further converted by gut commensal bacteria into se
Autor:
David T. Breault, Wanshu Qi, Jose Ordovas-Montanes, Sarah Dubois, Diana L. Carlone, Manasvi S. Shah, Daniel Zeve, Joshua de Sousa Casal, Sophie Hafner, Eric Stas, Jeffrey M. Karp, Xiaolei Yin, Erin Syverson, Prabhath Mannam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Nature Communications
Nature Communications
Enteroendocrine (EE) cells are the most abundant hormone-producing cells in humans and are critical regulators of energy homeostasis and gastrointestinal function. Challenges in converting human intestinal stem cells (ISCs) into functional EE cells,
Publikováno v:
Stem Cell Reports
Summary Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cance