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Autor:
Hong Tao, Qikuan Hu, Hong Zhu, Linna Zhang, Zhangping Chen, Shuhong Chi, Huimei Cao, Tao Sun, Shengnan Guo, Jijuan Yang
Publikováno v:
Molecular Medicine Reports
No effective treatment is currently available for neurodegenerative diseases, and existing pharmacotherapy is inconsistent with severe side effects. Cell replacement therapy is promising for neurodegenerative disease treatment, and the induction of n
Autor:
Ming Yang, Liying Yan, Xinyi Ma, Yueli Cui, Jie Qiao, Lu Wen, Jun Yong, Jie Ren, Shu Zhang, Fuchou Tang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The anterior pituitary gland plays a central role in regulating various physiological processes, including body growth, reproduction, metabolism and stress response. Here, we perform single-cell RNA-sequencing (scRNA-seq) of 4113 individual cells fro
Autor:
Todd M. Brusko, Michael V. Wiles, David V. Serreze, Cheng Ye, Benjamin E. Low, John P. Driver
Publikováno v:
J Immunol
The CD27–CD70 costimulatory pathway is essential for the full activation of T cells, but some studies show that blocking this pathway exacerbates certain autoimmune disorders. In this study, we report on the impact of CD27–CD70 signaling on disea
Autor:
Amania A. Sheikh, Joanna R Groom
Publikováno v:
Cellular and Molecular Immunology
During viral infection, immune cells coordinate the induction of inflammatory responses that clear infection and humoral responses that promote protection. CD4+T-cell differentiation sits at the center of this axis. Differentiation toward T-helper 1
Publikováno v:
Journal of Cellular and Molecular Medicine
Yin yang 2 (YY2) is a multifunctional zinc finger protein that belongs to the yin yang (YY) family. YY2 has dual function in regulating gene expression, as it could act either as a transcriptional activator or as a repressor of its target genes. YY2
Autor:
Daniel L. Matera, Brendon M. Baker, Yi Tang, Amy L. Strong, Chase A. Pagani, Stephen J. Weiss, Amanda K. Huber, Shuli Li, Mohamed Said, Michael T. Longaker, Reagan Nelson, Ginny Ching Yun Hsu, Benjamin Levi, Simone Marini, Noelle D. Visser, Joseph A. Greenstein, Karthik R. Padmanabhan, Andrea A. Poli, Charles Hwang, Aaron W. James, Nicole Patel
Publikováno v:
J Clin Invest
Cells sense the extracellular environment and mechanical stimuli and translate these signals into intracellular responses through mechanotransduction, which alters cell maintenance, proliferation, and differentiation. Here we use a mouse model of tra
Autor:
Yichun Kong, Wei Zhang
Publikováno v:
Journal of Cellular and Molecular Medicine
The purpose of this study was to investigate whether Yes‐associated protein (YAP) activation and proliferation of retinal Müller cells play a role in the development of TGF‐β‐induced retinal fibrosis. We studied the effects of YAP activation
Autor:
Hiroyuki Hosokawa, Ellen V. Rothenberg
Publikováno v:
Nat Rev Immunol
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signalling, a core group of transcription factors have essential roles in
Publikováno v:
Cellular and Molecular Life Sciences. 78:2199-2212
It is critical to specify a signal that directly drives the transition that occurs between cell states. However, such inferences are often confounded by indirect intercellular communications or secondary transcriptomic changes due to primary transcri
Autor:
Avital Horwitz, Ruth Birk
Publikováno v:
Molecular Neurobiology. 58:78-91
Bardet-Biedl syndrome (BBS) is an autosomal recessive syndrome presenting with retinal dystrophy, cognitive impairment, and obesity. BBS is characterized by elevated endoplasmic reticulum (ER) stress in the early stages of adipocyte and retinal devel