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Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1756-1771 (2018)
Summary: The pluripotent state of embryonic stem cells (ESCs) is defined by its transcriptome and epigenome. The chromatin reader Brd4 determines ESC identity. Although Brd4 regulation in gene transcription has been well described, its contribution t
Autor:
Rajneesh Srivastava, Sarath Chandra Janga, Yongyao Fu, Amina Abdul Qayum, Byunghee Koh, Mark H. Kaplan, Benjamin J. Ulrich
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
Cytokine genes are regulated by multiple regulatory elements that confer tissue-specific and activation-dependent expression. The cis-regulatory elements of the gene encoding IL-9, a cytokine that promotes allergy, autoimmune inflammation and tumor i
Autor:
Simone Bischetti, Artem Smirnov, Eleonora Candi, Anna Maria Lena, Angela Cappello, Emanuele Panatta, Alessandro Mauriello, Gennaro Melino, Margherita Annicchiarico-Petruzzelli, Lucia Anemona
Publikováno v:
Oncogene
Development and maintenance of healthy stratified epithelia require the coordination of complex transcriptional programmes. The transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and homeostasis. Anal
Autor:
Linglu Jia, Yawen Ji, Yixiao Xing, Panpan Zhang, Xin Xu, Bin Zhao, Yunpeng Zhang, Xuan Wu, Ting Ting Jia
Publikováno v:
International Journal of Molecular Medicine
1α, 25‑dihydroxyvitamin D3 (1,25‑D3), an active vitamin D metabolite, is a well‑known regulator of osteogenic differentiation. However, how 1,25‑D3 regulates osteogenic differentiation in human periodontal ligament stem cells (hPDLSCs) remai
Autor:
Lei Chen, Qianyin Li, Yuping Gu, Qin Zhou, Jianing Liu, Yajun Xie, Dongsheng Ni, Yamin Liu, Yafei Wu, Yanxia Hu, Qingling He
Publikováno v:
Biochemical and Biophysical Research Communications. 504:885-891
During kidney development, the balance between self-renewal and differentiation of metanephric mesenchyme (MM) cells, mainly regulated by Sine oculis-related homeobox 2 (Six2), is critical for forming mature kidney. L-gulono-γ-lactone oxidase (Gulo)
Autor:
Dwayne Holmes, Lisa Gasparotto, Paulien Cornelissen-Steijger, Vivi M. Heine, Prisca S. Leferink, Aishwarya G. Nadadhur, Lisa Hinz
Publikováno v:
Stem Cell Research, 32, 25-34. Elsevier
Nadadhur, A G, Leferink, P S, Holmes, D, Hinz, L, Cornelissen-Steijger, P, Gasparotto, L & Heine, V M 2018, ' Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro ', Stem Cell Research, vol. 32, pp. 25-34 . https://doi.org/10.1016/j.scr.2018.08.017
Stem Cell Research, Vol 32, Iss, Pp 25-34 (2018)
Nadadhur, A G, Leferink, P S, Holmes, D, Hinz, L, Cornelissen-Steijger, P, Gasparotto, L & Heine, V M 2018, ' Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro ', Stem Cell Research, vol. 32, pp. 25-34 . https://doi.org/10.1016/j.scr.2018.08.017
Stem Cell Research, Vol 32, Iss, Pp 25-34 (2018)
The neural tube consists of neural progenitors (NPs) that acquire different characteristics during gestation due to patterning factors. However, the influence of such patterning factors on human pluripotent stem cells (hPSCs) during in vitro neural d
Publikováno v:
Biochemical and Biophysical Research Communications. 505:119-125
The prevention and treatment of coronary heart disease (CHD) is a difficult problem to be solved. More and more studies have found that circular RNAs (circRNAs) may play important roles in the development of CHD. Here detection of vascular smooth mus
Autor:
Pann-Ghill Suh, Yohan Lee, Dougu Nam, Keon Woo Khim, Byung-Gyu Kim, Sun Sil Choi, So-Ra Yoon, Jae Min Lee, Kyungjae Myung, Jang Hyun Choi
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 10, Pp 1-11 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor that regulates adipocyte differentiation and glucose homeostasis. The transcriptional activity of PPARγ is regulated not only by ligands but also by
Autor:
Shigeru B. H. Ko, Saeko Sato, Hiromi Kimura, Yuhki Nakatake, Tomohiko Akiyama, Nana Chikazawa-Nohtomi, Hideomi Ida, Kei-ichiro Ishiguro, Sravan Kumar Goparaju, Masato Nagino, Minoru S.H. Ko, Yukihiro Yokoyama
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2018)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Transplantation of pancreatic β cells generated in vitro from pluripotent stem cells (hPSCs) such as embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) has been proposed as an alternative therapy for diabetes. Though ma
Autor:
Navid Nasiri, Mousa Kehtari, Javad Hashemi, Maryam Nouri Aleagha, Ehsan Saburi, Sepehr Torabinejad, Gholamreza Khamisipour, Fatemeh Soleimanifar, Mohammad Foad Abazari, Seyed Ehsan Enderami, Javad Amini Mahabadi, Hossein Mahboudi
Publikováno v:
Gene. 671:50-57
Pancreatic differentiation of stem cells will aid treatment of patients with type I diabetes mellitus (T1DM). Synthetic biopolymers utilization provided extracellular matrix (ECM) and desired attributes in vitro to enhance conditions for stem cells p