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Autor:
Clark A. Bonham, Dharshan Sivaraj, Michael T. Longaker, Jagannath Padmanabhan, Kellen Chen, Dominic Henn, Derrick C. Wan, Michael Januszyk, Artem A. Trotsyuk, Geoffrey C. Gurtner, Michelle Griffin, Hudson Choi Kussie
Publikováno v:
Advances in Wound Care. 11:466-478
Objective: After injury, humans and other mammals heal by forming fibrotic scar tissue with diminished function, and this healing process involves the dynamic interplay between resident cells withi...
Autor:
Pablo Martín-Vasallo, Ricardo Gutiérrez, Deborah Rotoli, Julio Ávila, Manuel Morales, Lucio Díaz-Flores
Publikováno v:
J Histochem Cytochem
Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cel
Publikováno v:
Stem Cell Reviews and Reports. 18:1434-1443
Human pluripotent stem cells (hPSCs) have great potential for disease modeling, drug discovery, and regenerative medicine as they can differentiate into many different functional cell types via directed differentiation. However, the application of di
Publikováno v:
Trends in Molecular Medicine. 28:8-11
Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows
Publikováno v:
Stem Cells and Development. 30:1153-1170
Diabetes is a pandemic manifested through glucose dysregulation mediated by inadequate insulin secretion by beta cells. A beta cell replacement strategy would transform the treatment paradigm from pharmacologic glucose modulation to a genuine cure. S
Autor:
Aryeong Choi, Yong Woo Jung, Seohoon Jin, Kyong Hoon Kim, Heonju Song, Sang Hoon Kim, Jaebong Jang, Hanbyeul Choi, Kyungim Kim
Publikováno v:
Molecules and Cells
Memory T (TM) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how TM cel
Autor:
Monika Madej, Jenny Lange, Simon Eaton, Patrizia Ferretti, Michael Flower, Olivia Gillham, Francesco Muntoni, Francesco Tedesco, Reem Alkharji, Giulia Ferrari
Publikováno v:
Glia. 70:466-490
In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits. However, there is currently an incomplete understanding about the function of the multiple dys
Autor:
Fatemeh Taheri, Soheila Fattahi, Mahdi Ghatrehsamani, Maryam Anjomshoa, Faramarz Mohammad Alibeigi, Nader Bagheri, Hedayatollah Shirzad, Monireh Karimi
Publikováno v:
Int J Exp Pathol
Bladder cancer (BC) is one of the most prevalent cancers around the world and, if not treated well, has high morbidity and mortality. Many studies have indicated that there may be various roles for the aryl hydrocarbon receptor (AHR) in the immune sy
Publikováno v:
Cellular & Molecular Biology Letters, Vol 26, Iss 1, Pp 1-23 (2021)
Cellular & Molecular Biology Letters
Cellular & Molecular Biology Letters
Owing to an increase in the aging population, osteoporosis has become a severe public health concern, with a high prevalence among the elderly and postmenopausal adults. Osteoporosis-related fracture is a major cause of morbidity and mortality in eld
Autor:
Jia-Xin Jiang, Sunny Xia, Markus Grompe, Christine E. Bear, Changyi Cui, Hiroshi Suemizu, Yuichiro Higuchi, Avrilynn Ding, Mina Ogawa, Onofrio Laselva, Shinichiro Ogawa, Craig Dorrell, Donghe Yang, Marcela Hernandez
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
The derivation of mature functional cholangiocytes from human pluripotent stem cells (hPSCs) provides a model for studying the pathogenesis of cholangiopathies and for developing therapies to treat them. Current differentiation protocols are not effi