Zobrazeno 1 - 10
of 1 007
pro vyhledávání: ''
Publikováno v:
Stem Cell Reports
Summary Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cance
Publikováno v:
Epigenomics. 13:1845-1848
Autor:
Andrew J. Lund, Istvan Mody, John Huang, Inma Cobos, William E. Lowry, Marcos Otero-Garcia, Justin Langerman, Ranmal A. Samarasinghe, Kathrin Plath, Damon Polioudakis, Shan Sabri, Xiaofei Wei, Bennett G. Novitch, Daniel H. Geschwind, Thomas F. Allison
Publikováno v:
Stem cell reports, vol 16, iss 10
Stem Cell Reports
Stem Cell Reports
Summary The specification of inhibitory neurons has been described for the mouse and human brain, and many studies have shown that pluripotent stem cells (PSCs) can be used to create interneurons in vitro. It is unclear whether in vitro methods to pr
Autor:
Paula Stein, Russell J. Butterfield, Carmen J. Williams, Roberta Menafra, Christina M. Smith, Jingtao Guo, Peter G. Hendrickson, Bradley D. Weaver, Nicholas E. Johnson, Bradley R. Cairns, Susan L. Kloet, Edward J. Grow, Silvère M. van der Maarel, Sean C. Shadle
Publikováno v:
Nature Genetics
Nat Genet
Nature Genetics, 53(8), 1207-1220. NATURE PORTFOLIO
Nat Genet
Nature Genetics, 53(8), 1207-1220. NATURE PORTFOLIO
In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is required for forming cultured two-cell (2C)-like cells. Remarkably, in mouse embr
Autor:
F. Jeffrey Dilworth, Tapan Sharma, Daniel C.L. Robinson, Anthony N. Imbalzano, Hanna Witwicka
Publikováno v:
Nucleic Acids Research
Skeletal muscle regeneration is mediated by myoblasts that undergo epigenomic changes to establish the gene expression program of differentiated myofibers. mSWI/SNF chromatin remodeling enzymes coordinate with lineage-determining transcription factor
Autor:
Shih Wei Chen, Yeh Shiu Chu, Nien-Jung Chen, Jong Ling Fuh, Shu Cian Chen, Ming-Ji Fann, Yu Hui Wong, Yu Sheng Hung
Publikováno v:
Stem Cell Reports
Summary Microglia, the immune cells of the central nervous system, play critical roles in brain physiology and pathology. We report a novel approach that produces, within 10 days, the differentiation of human induced pluripotent stem cells (hiPSCs) i
Autor:
Deyou Zheng, Jose M. Silva, Haruhiko Koseki, Carmit Bar, Phillip M. Galbo, Hequn Liu, Víctor Valdés, Dejian Zhao, Idan Cohen, Elena Ezhkova
Publikováno v:
Genes Dev
Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. Howev
Publikováno v:
Functional & Integrative Genomics. 21:205-214
The dysfunction of placenta development is correlated to the defects of pregnancy and fetal growth. The detailed molecular mechanism of placenta development is not identified in humans due to the lack of material in vivo. Trophoblast (TB) lineage der
Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages
Publikováno v:
Molecular Biology Reports. 47:9595-9607
Mitochondrial dysfunction plays a crucial role in the central pathogenesis of insulin resistance and type 2 diabetes mellitus. Macrophages play important roles in the pathogenesis of insulin resistance. Lauric acid is a 12-carbon medium chain fatty a
Autor:
Yang Yang, Hao Du, Xiaoxu Liu, Yan Wang, Zhuojuan Luo, Haitong Fang, Chen Chen, Fengchao Wang, Chengqi Lin, Siyan Meng, Zhuanzhuan Che, Chenghao Guo, Manman Xu
Publikováno v:
Journal of Molecular Cell Biology
Regulation of RNA stability plays a crucial role in gene expression control. Deadenylation is the initial rate-limiting step for the majority of RNA decay events. Here, we show that RING finger protein 219 (RNF219) interacts with the CCR4–NOT deade