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Publikováno v:
Cell Biology International. 45:2544-2556
Indoleamine 2, 3-dioxygenase (IDO) catabolizes tryptophan, mediates immunomodulatory functions, and is released by stromal cells such as mesenchymal stem cells. The aims of this study were to investigate the effects of IDO silencing on immunosuppress
Autor:
Tohru Natsume, Tomohiko Okazaki, Yasushi Okada, Yukiko Gotoh, Shun-ichiro Iemura, Saeko Aoyama-Ishiwatari
Publikováno v:
The Journal of Immunology. 206:154-163
Viral RNA in the cytoplasm of mammalian host cells is recognized by retinoic acid–inducible protein–I–like receptors (RLRs), which localize to cytoplasmic stress granules (SGs). Activated RLRs associate with the mitochondrial adaptor protein IP
Autor:
Pei Hsun Wu, Ralph H. Hruban, Jacob S. Sarnecki, Vikram Deshpande, Jef D. Boeke, Mikhail Gorbounov, Zhi Li, Daniel Ardeljan, Lindsay M. Payer, Agata Smogorzewska, Chunhong Liu, David Fenyö, Kathleen H. Burns, Jared P. Steranka, Andrew J. Holland, Martin S. Taylor
Publikováno v:
Nature structural & molecular biology
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that nontra
Autor:
Estanislao Nistal-Villán, Susana Esteban-Rubio, Jesús Presa, Sergio Rius-Rocabert, Angel Ayuso-Sacido
Publikováno v:
Journal of Interferon & Cytokine Research. 39:711-719
Interferon (IFN), the first ever-described cytokine, has a potent activity against viruses. Soon since its discovery, quantification of IFN has been an important issue. Most of the traditional methods to measure IFN biological activity rely on indire
Autor:
Connor G. G. Bamford, Cuncai Guo, Jonathon D. Coey, John McLauchlan, Benjamin Lang, Steeve Boulant, Dorothee Reuss, Swathi Sukumar, Megan L. Stanifer
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Guo, C, Reuss, D, Coey, J D, Sukumar, S, Lang, B, McLauchlan, J, Boulant, S, Stanifer, M L & Bamford, C G G 2021, ' Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins ', Frontiers in immunology, vol. 12, 772588 . https://doi.org/10.3389/fimmu.2021.772588
Frontiers in Immunology, Vol 12 (2021)
Guo, C, Reuss, D, Coey, J D, Sukumar, S, Lang, B, McLauchlan, J, Boulant, S, Stanifer, M L & Bamford, C G G 2021, ' Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins ', Frontiers in immunology, vol. 12, 772588 . https://doi.org/10.3389/fimmu.2021.772588
Interferon lambdas (IFN{lambda}) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver and gastrointestinal tract. Humans have four IFN{lambda}s (1-4) where IFN{lambda}1-3
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1008874 (2021)
PLoS Computational Biology
PLoS Computational Biology
Respiratory viruses present major public health challenges, as evidenced by the 1918 Spanish Flu, the 1957 H2N2, 1968 H3N2, and 2009 H1N1 influenza pandemics, and the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Seve
Autor:
Maritza Puray-Chavez, Dhaval P. Bhatt, Steven L. Brody, James E. Crowe, D. Neil Hayes, Emily M. Cousins, Adam L. Bailey, Amjad Horani, Zhuoming Liu, Dennis Goldfarb, Sean P. J. Whelan, Nakyung Lee, M. Ben Major, Jenna E. Eschbach, Paul W. Rothlauf, Erica W. Cloer, Jennifer L Elliott, Kyle M. LaPak, Ria Jasuja, Pavlo Gilchuk, Hung R. Vuong, Christian Shema Mugisha, Heejoon Jo, Sebla B. Kutluay, Keanu Davis, Travis P. Schrank, Megan J. Agajanian, Kasyap Tenneti, Michael S. Diamond, Dana Q. Lawson, Laura A. VanBlargan
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports, Vol 36, Iss 2, Pp 109364-(2021)
Cell Reports
article-version (status) pre
article-version (number) 1
Cell Reports, Vol 36, Iss 2, Pp 109364-(2021)
Cell Reports
SARS-CoV-2 spike (S) variants govern transmissibility, responsiveness to vaccination and disease severity. In a screen for new models of SARS-CoV-2 infection, we identified human H522 lung adenocarcinoma cells as naturally permissive to SARS-CoV-2 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ab279dc74bdfceae4b25f51be1a1c5
https://doi.org/10.1101/2021.03.01.433431
https://doi.org/10.1101/2021.03.01.433431
Autor:
Xue-cai Yang, Tian-Yu Zhao, Jiang-Long Du, Jing Liu, Peng Ma, Xiao‐ye Jia, Chen Wang, Yan Zeng, Xin Cao, Kui-Zheng Cai, Fan-Fan Chang, Yu-jia Xue, Hai-Zhen Wang, Xue‐mei Wan, Zhongren Ma
Publikováno v:
Journal of Cellular and Molecular Medicine
Autor:
Katsunori Yanagihara, Kazumi Umeki, Yatsuki Aratake, Mineki Saito, Ikuo Yamamoto, Hiroo Hasegawa, Yuuki Hashikura, Kunihiko Umekita, Akihiko Okayama, Hajime Nomura
Publikováno v:
Human Cell. 32:185-192
We previously reported the diversity of structure and integration sites of human T-cell leukemia virus type 1 (HTLV-1) provirus among different MT-2 cell lines. This raised the question as to whether cell phenotypes also differed among MT-2 cell line
Autor:
Aviad Tsherniak, Andrew D. Cherniack, Francisca Vazquez, Erez Y. Levanon, William C. Hahn, Matthew Meyerson, Michael K. Kiessling, Tao Zou, Alexandru P. Ivan, Diana Cai, Ilana Buchumenski, Galen F. Gao, Hugh S. Gannon, Ashton C. Berger, Jonathan T. Goldstein, Peter S. Choi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essen