Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lance L. Munn"'
Autor:
James A. Tyrrell, Gang Cheng, Janet M. Tse, Rakesh K. Jain, Sarah A. Wilcox-Adelman, Yves Boucher, Lance L. Munn
Publikováno v:
Proceedings of the National Academy of Sciences. 109:911-916
Uncontrolled growth in a confined space generates mechanical compressive stress within tumors, but little is known about how such stress affects tumor cell behavior. Here we show that compressive stress stimulates migration of mammary carcinoma cells
Autor:
Michael M. Dupin, Lance L. Munn
Publikováno v:
Annals of Biomedical Engineering. 36:534-544
For more than a century, pioneering researchers have been using novel experimental and computational approaches to probe the mysteries of blood flow. Thanks to their efforts, we know that blood cells generally prefer to migrate to the axis of flow, t
Autor:
Zoe N. Demou, Rakesh K. Jain, Trevor D. McKee, Lance L. Munn, Jean Yannis Perentes, Michael Awad, Yves Boucher, Xiaoye Wang
Publikováno v:
Cancer Research. 65:5674-5682
Defective fibrillar collagen polymerization in primary tumors has been correlated with increased metastasis. However, it is unclear how collagen organization influences tumor invasion. In this study, we show that collagen I polymerized without telope
Autor:
Catharina de Lange Davies, Carla Mouta-Carreira, Rakesh K. Jain, Robert J. Melder, Yves Boucher, Lance L. Munn
Publikováno v:
Microvascular Research. 62:26-42
Interactions between endothelial cell receptors and the extracellular matrix (ECM) play a critical, yet poorly understood role in angiogenesis. Based on the anti-adhesive role of decorin, we hypothesized that decorin binding to ECM molecules such as
Mammalian cells are covered by a surface proteoglycan (glycocalyx) layer, and it is known that blood vessel-lining endothelial cells use the glycocalyx to sense and transduce the shearing forces of blood flow into intracellular signals. Tumor cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf55eff1df54d9df3d5da6c311139df
https://europepmc.org/articles/PMC4249644/
https://europepmc.org/articles/PMC4249644/
Publikováno v:
Scopus-Elsevier
We present the formulation and testing of a mathematical model for the kinetics of homotypic cellular aggregation. The model considers cellular aggregation under no-flow conditions as a two-step process. Individual cells and cell aggregates 1) move o
Publikováno v:
Biophysical Journal. 71:466-478
The binding of circulating cells to the vascular wall is a central process in inflammation, metastasis, and therapeutic cell delivery. Previous in vitro studies have identified the adhesion molecules on various circulating cells and the endothelium t
Publikováno v:
Journal of Immunological Methods. 166:11-25
We present the development and testing of a novel assay of lymphocyte adhesion based on time-resolved morphological measurements of intercellular aggregation. Homotypic lymphocyte aggregation is induced according to various protocols and monitored fo
Although millions of cells are shed from a tumour every day, haematogenous metastasis is believed to be very inefficient. This inefficiency is widely assumed to be a result of the destruction of cells in the bloodstream by shear stress and the immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901fa607be00333f532d29c09b3712fd
https://europepmc.org/articles/PMC2712886/
https://europepmc.org/articles/PMC2712886/
Autor:
Erik B. Friedrich, Andrew M. Tager, Andrew D. Luster, Christer Owman, Emerson Liu, Robert E. Gerszten, Annika Pettersson, Lance L. Munn
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 23(10)
Objective—Leukotriene B4(LTB4) has been implicated in the trafficking of monocytes to inflammatory pathologic conditions, such as transplant rejection and atherosclerosis. The aim of this study was to determine the mechanisms by which LTB4contribut