Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Quansheng Zhou"'
Publikováno v:
Toxicology Letters. 278:9-17
Lyn is a proto-oncogene overexpressed and constitutively activated in lymphoma, and plays an important role in lymphoma initiation and malignant progression. Hence, the oncogenic Lyn has recently been targeted for novel anti-lymphoma drug discovery;
Autor:
Zhe Zhao, Tong Zhang, Yingnan Qiao, Mei Meng, Jindan Qi, Xiaohua Wang, Bin Zhang, Quansheng Zhou, Shijie Tan, Mengli Zhang
Publikováno v:
Biochemical Pharmacology. 185:114423
Metastatic melanoma has a very high mortality rate despite the availability of chemotherapy, radiotherapy, and immunotherapy; therefore, more effective therapeutics are needed. The Hippo pathway plays an inhibitory role in melanoma progression, but t
Autor:
Yanyan Pan, Bin Zhang, Wenming Liu, Mei Meng, Longsheng Du, Zhifei Cao, Ping Yang, Quansheng Zhou, Zhenlun Gu
Publikováno v:
Toxicology and Applied Pharmacology. 287:98-110
Accumulated data has shown that various vasculogenic tumor cells, including gastric cancer cells, are able to directly form tumor blood vessels via vasculogenic mimicry, supplying oxygen and nutrients to tumors, and facilitating progression and metas
Publikováno v:
Journal of cellular physiology. 234(7)
Metastatic melanoma accounts for 60% of death for skin cancer. Although great efforts have been made to treat the disease, effective drugs against metastatic melanoma still lack at the clinical setting. In the current study, we found that lycorine, a
Publikováno v:
Vascular pharmacology. 117
Vascular endothelial protein tyrosine phosphatase (VE-PTP) is essential for endothelial cells (ECs) adherens junction and vascular homeostasis; however, the regulatory mechanism of VE-PTP transcription is unknown, and a drug able to promote VE-PTP ex
Publikováno v:
Biochemical pharmacology. 126
Leukemia cells aberrantly overexpress senescence-suppression telomerase reverse transcriptase (TERT) and down-regulate key senescence-promoting genes to escape complete senescence, resulting in immortalization and malignant progression. Accordingly,
Publikováno v:
Anti-Cancer Drugs. 24:667-676
Malignant melanoma is the most aggressive form of skin cancer. Although various antimelanoma approaches have been used in the clinics to treat the disease over the last three decades, none of the drugs significantly prolonged the survival of metastat
Autor:
Bingxue Shang, Meimei Bao, Gaochuan Zhang, Shasha Zhang, Ruifang Liu, Quansheng Zhou, Jian Tu, Ping Yang, Zhifei Cao, Yanyan Pan
Publikováno v:
Pigment Cell & Melanoma Research. 25:630-638
Melanoma cells actively participate in tumor angiogenesis and vasculogenic mimicry. However, anti-angiogenic therapy in patients with melanoma has not shown a significant survival gain. Thus, new anti-melanoma angiogenic and vasculogenic drugs are hi
Publikováno v:
Biochemical and biophysical research communications. 476(4)
Thrombomodulin (TM) is an endothelial cell membrane protein and plays critical roles in anti-thrombosis, anti-inflammation, vascular endothelial protection, and is traditionally regarded as a "vascular protection god". In recent years, although TM ha
Autor:
Robert H. Silverman, Fahad Al-Zoghaibi, Ji Zhao, Quansheng Zhou, Therese Wiedmer, Aimin Zhou, Peter J. Sims
Publikováno v:
Blood. 95:2593-2599
Interferons (IFNs) mediate their diverse biologic activities through induction of the expression of multiple genes. Whereas the mode of action of certain of these IFN-regulated genes has been well characterized, most of the molecular and cellular eve