Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
Autor:
Huamin Wang, Marina Pasca di Magliano, Nina Steele, Edna Cukierman, Janusz Franco-Barraza, Igor Astsaturov, Kerry S. Campbell, Tiffany Luong, Ralph Francescone, Benjamin L. Allen, Charline Ogier, Andres J. Klein-Szanto, Kathy Q. Cai, Debora Barbosa Vendramini Costa
Publikováno v:
Cancer Research. 81:PO-096
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, with a 5-year survival of 10%. A major feature of PDAC is the presence of a dense fibrous stroma, due to the expansion of cancer associated fibroblasts (CAFs) and their
Autor:
Joel Gabre, Jianwen Que, Angela J. Yoon, Ricardo Cruz-Acuna, Gary W. Falk, Shoji Natsugoe, Adam J. Bass, Julian A. Abrams, Tatiana A. Karakasheva, Lorenzo Ferri, Veena Sangwan, Anil K. Rustgi, Timothy C. Wang, Hiroshi Nakagawa, Varun Sahu, Kelly A. Whelan, Gregory G. Ginsberg, Elizabeth Philipone, J. Alan Diehl, Veronique Giroux, Hisatsugu Maekawa, Andres J. Klein-Szanto, Devraj Basu, Masataka Shimonosono, Takashi Kijima
Publikováno v:
Curr Protoc Stem Cell Biol
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat and among the deadliest human malignancies. We describe protocols to initiate, grow, passage, and characterize patie
Autor:
Fatemeh Momen-Heravi, Hiroshi Nakagawa, Satoshi Takada, Veena Sangwan, Norihiro Matsuura, Andres J. Klein-Szanto, Angela J. Yoon, Koji Tanaka, Samuel Flashner, Uma M. Sachdeva, Lorenzo E. Ferri, Masataka Shimonosono, Eishi Noguchi, J. Alan Diehl, Yasuto Tomita
Publikováno v:
Biomolecules, Vol 11, Iss 1479, p 1479 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Background: Alcohol (ethanol) consumption is a major risk factor for head and neck and esophageal squamous cell carcinomas (SCCs). However, how ethanol (EtOH) affects SCC homeostasis is incompletely understood. Methods: We utilized three-dimensional
Publikováno v:
Biochemical Pharmacology. 140:8-15
Proprotein convertases are serine proteases responsible for the cleavage and subsequent activation of protein substrates, many of them relevant for the development of an ample variety of diseases. Seven of the PCs, including furin and PACE4, recogniz
Autor:
Koji Tanaka, Yoshiaki Kita, Jeffrey D. Winkler, Andres J. Klein-Szanto, Douglas S. Darling, Hiroshi Nakagawa, Satish Srinivasan, Manti Guha, Anil K. Rustgi, Ravi K. Amaravadi, Narayan G. Avadhani, Kelly A. Whelan, Mitsuteru Natsuizaka, Prasanna M. Chandramouleeswaran, Shoji Natsugoe
Publikováno v:
Oncogene
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient out
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma
Autor:
Carsten Weishaupt, Björn Kemper, Agatha Stegemann, Mauro Picardo, Andres J. Klein-Szanto, Arianna Mastrofrancesco, Markus Böhm, Dieter Metze
Publikováno v:
Acta Dermato Venereologica. 100:adv00157
Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing prefo
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Publikováno v:
Journal of Urology. 177:346-352
We determined the frequency of mTOR/p70S6 kinase signaling pathway activation in clear cell renal cell carcinoma.Phospho-S6 (Ser235/236) and phospho-mTOR (Ser2448) staining was performed on renal tumor tissue microarrays containing 29 clear cell rena
Autor:
Andres J. Klein-Szanto, Adam J. Bass, Anil K. Rustgi, Kwok K. Wong, Eric K. Lee, J. Alan Diehl, Zhaorui Lian
Publikováno v:
Cancer biologytherapy. 16(5)
Cyclin D1 is frequently overexpressed in esophageal squamous cell carcinoma (ESCC) and is considered a key driver of this disease. Mutations in FBXO4, F-box specificity factor that directs SCF-mediated ubiquitylation of cyclin D1, occur in ESCC with