Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Paul A, Goepfert"'
Autor:
Kai Qin, Wyatt J. McDonnell, Christian M Warren, Mina John, Abha Chopra, Simon Mallal, Silvana Gaudieri, Ling Yue, Rama Gangula, Becker M.P. Law, Shay Leary, Ramesh Ram, Mark A. Pilkinton, Paul A. Goepfert, Spyros A. Kalams, Louise Barnett, Jennifer Currenti, Anuradha Sooda, Sonya L. Heath, Anju Bansal, Eric Alves
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations with
Autor:
Leon A. Venegas, Anju Bansal, Ayub Ali, Paul A. Goepfert, Otto O. Yang, Margaret C Costanzo, Jianming Tang, Mark A. Brockman, Kai Qin, Ying Dang, N. Manjunath, Mika N Gehre, Sarah Sterrett, Sojan Abraham, June Kan-Mitchell
Publikováno v:
J Clin Invest
CD8(+) T cell responses restricted by MHC-E, a nonclassical MHC molecule, have been associated with protection in an SIV/rhesus macaque model. The biological relevance of HLA-E–restricted CD8(+) T cell responses in HIV infection, however, remains u
Autor:
Vincent H. Wu, Emma Gostick, Ahmed Gaballa, Sian Llewellyn-Lacey, Piotr Nowak, Sara Falck-Jones, Johan K. Sandberg, Sindhu Vangeti, Son Nguyen, Quirin Hammer, Meng Yu, Anna Smed-Sörensen, David Price, Marcus Buggert, Christian Brander, André Perez-Potti, Michael R. Betts, Takuya Sekine, Paul A. Goepfert, Michael Uhlin, Jean-Baptiste Gorin
Publikováno v:
Science Immunology
CD8+ T cell exhaustion is a hallmark of many cancers and chronic infections. In mice, T cell factor 1 (TCF-1) maintains exhausted CD8+ T cell responses, whereas thymocyte selection-associated HMG box (TOX) is required for the epigenetic remodeling an
Publikováno v:
J Virol
Because of HIV’s vast sequence diversity, the ability of the CD8 T-cell response to recognize several variants of a single epitope is an important consideration for vaccine design. Cross-recognition of viral epitopes by CD8 T cells is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a507ddaea8e3d8941eedc9eff16358b
https://europepmc.org/articles/PMC6955250/
https://europepmc.org/articles/PMC6955250/
Autor:
Omu Anzala, Susan Allen, Shabir Lakhi, Etienne Karita, Jianming Tang, Paul A. Goepfert, Matthew Price, Heather A. Prentice, Hailin Lu, Anatoli Kamali, Jill Gilmour, Eduard J. Sanders, Eric Hunter
Publikováno v:
Journal of Virology. 90:10423-10430
In individuals with HIV-1 infection, depletion of CD4 + T cells is often accompanied by a malfunction of CD8 + T cells that are persistently activated and/or exhausted. While the dynamics and correlates of CD4 counts have been well documented, the sa
Autor:
Sarah Sterrett, Jacob K Files, Kai Qin, Kristen W. Cohen, Anju Bansal, Stephen C. De Rosa, Paul A. Goepfert, Sushma Boppana, Andrew Fiore-Gartland
Publikováno v:
J Infect Dis
HLA-I–associated human immunodeficiency virus (HIV) adaptation is known to negatively affect disease progression and CD8 T-cell responses. We aimed to assess how HLA-I–associated adaptation affects HIV vaccine–induced CD8 T-cell responses in 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4f403bdcfa3d9cfbf94e1201d394f8
https://europepmc.org/articles/PMC6782105/
https://europepmc.org/articles/PMC6782105/
Autor:
Steffanie Sabbaj, Alexandra Duverger, Olaf Kutsch, Lillian Seu, Frederic Wagner, Laura Timares, Paul A. Goepfert, Christopher Tidwell, Andrew O. Westfall
The tetraspanin CD151 is a marker of aggressive cell proliferation and invasiveness for a variety of cancer types. Given reports of CD151 expression on T cells, we explored whether CD151 would mark T cells in a hyperactivated state. Consistent with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2013a692118ae58f0f9ee79d059196
https://europepmc.org/articles/PMC5654656/
https://europepmc.org/articles/PMC5654656/
Autor:
Philippa C Matthews, Anju Bansal, Jiyu Yan, Steffanie Sabbaj, David Heckerman, Paul A. Goepfert, Olusimidele T. Akinsiku, Philip J. R. Goulder, Sonya L. Heath, Jonathan M. Carlson
Publikováno v:
Retrovirology, Vol 6, Iss Suppl 3, p P233 (2009)
Europe PubMed Central
Retrovirology
Europe PubMed Central
Retrovirology
Methods Using MHC-I associated HIV-1 polymorphisms in gag, pol and nef sequences from 730 South Africans with chronic infection; over 957 potential ARF epitopes were predicted. Of these, 25 potential cryptic epitopes (CE) were selected for testing us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f485c31fcfe80b57110051c39c8650e
https://ora.ox.ac.uk/objects/uuid:aea2c3b5-80c4-49b7-bedb-24348f46e360
https://ora.ox.ac.uk/objects/uuid:aea2c3b5-80c4-49b7-bedb-24348f46e360
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 58:132-140
BACKGROUND Assays to measure the induction of HIV-1-specific CD8 T-cell responses often rely on measurements of indirect effector function such as chemokine and cytokine production, which may not reflect direct elimination of an invading pathogen. As
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 56:213-221
Understanding the correlates of immunity that control HIV-1 infection is imperative to our understanding of HIV-1 disease and vaccine development. HIV-1-specific cytotoxic T lymphocytes are fundamental to the control of viremia; however, which T-cell