Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lorna Rodriguez-Rodriguez"'
Autor:
Antons Martincuks, Pei-Chuan Li, Qianqian Zhao, Chunyan Zhang, Yi-Jia Li, Hua Yu, Lorna Rodriguez-Rodriguez
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Despite significant progress in cancer therapy over the last decades, ovarian cancer remains the most lethal gynecologic malignancy worldwide with the five-year overall survival rate less than 30% due to frequent disease recurrence and chemoresistanc
Externí odkaz:
https://doaj.org/article/96062329de784f1daec48555a07d0af9
Autor:
Yi Jia Li, Antons Martincuks, Qianqian Zhao, Chunyan Zhang, Hua Yu, Pei Chuan Li, Lorna Rodriguez-Rodriguez
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, Vol 10 (2020)
Despite significant progress in cancer therapy over the last decades, ovarian cancer remains the most lethal gynecologic malignancy worldwide with the five-year overall survival rate less than 30% due to frequent disease recurrence and chemoresistanc
Autor:
Lorna Rodriguez-Rodriguez, A. Buckley de Meritens, Aliza L. Leiser, Eugenia Girda, David L. Nelson, Ruth Stephenson
Publikováno v:
Gynecologic Oncology. 154:93
Autor:
Lorna Rodriguez-Rodriguez, Olena Taratula, Tamara Minko, Vatsal Shah, Olga B. Garbuzenko, Oleh Taratula
Publikováno v:
Clinical Cancer Research. 19:6193-6204
Purpose: The proposed project is aimed at enhancing the efficiency of epithelial ovarian cancer treatment and reducing adverse side effects of chemotherapy using nanotechnology. Overexpression of the CD44 membrane receptor results in tumor initiation
Autor:
Eugenia Girda, David L. Nelson, Lorna Rodriguez-Rodriguez, Malcolm Finlayson, Aliza L. Leiser, Ruth Stephenson, Alexandre Buckley de Meritens, Michael H. Silverman
Publikováno v:
Journal of Clinical Oncology. 36:TPS5608-TPS5608
TPS5608Background: Ovarian cancer often presents in advanced stages and is treated with platinum-based chemotherapy. However, many patients develop platinum-resistant disease with either failing to...
Autor:
Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Neelakandan Muthukumaran, Karl E. Miletti-González
Publikováno v:
Molecular Cancer Research. 4:511-520
Chronic inflammation is implicated in the pathophysiology of ovarian cancer. Tumor necrosis factor-α (TNF-α), a major inflammatory cytokine, is abundant in the ovarian cancer microenvironment. TNF-α modulates the expression of CD44 in normal T lym
Publikováno v:
Advanced drug delivery reviews. 65(13-14)
The efficacy of chemotherapy is substantially limited by the resistance of cancer cells to anticancer drugs that fluctuates significantly in different patients. Under identical chemotherapeutic protocols, some patients may receive relatively ineffect
Autor:
William N. Hait, Karl E. Miletti-González, Shiling Chen, Lorna Rodriguez-Rodriguez, Jin Ming Yang, Weichung Joe Shih, Kevin Apolito, Neelakandan Muthukumaran, Giuseppa N. Saglimbeni, Xiaohua Wu
Publikováno v:
Cancer research. 65(15)
Invasion and metastases of cancer cells and the development of resistance to anticancer therapies are the main causes of morbidity and mortality from cancer. For more than two decades, these two important but not clearly related aspects in the biolog
Autor:
G. Zotalis, D. G. Gibbon, Lorna Rodriguez-Rodriguez, I. Sancho-Torres, Weichung Joe Shih, C. Mesonero
Publikováno v:
Medical oncology (Northwood, London, England). 20(3)
CD44 is a cell surface receptor implicated in cancer progression and metastases. Malignant tumors may show a loss of CD44 splice control mechanisms. We investigated the role of CD44 splice variant expression in ovarian tumors and metastases, and its
Autor:
Lorna Rodriguez-Rodriguez, Darlene G. Gibbon, Clara Mesonero, Jean-Luc Miller Watelet, Inés Sancho-Torres
Publikováno v:
Gynecologic oncology. 79(2)
Objective. CD44 is a cell surface receptor implicated in tumor metastases. We have previously shown that there is a loss of CD44 splice control in clear cell carcinoma (CCCa) of the ovary. Our aim is to characterize the expression of CD44-3v, -5v, -7