Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Mandy L. Ford, Ching-Wen Chen, Kimberly M. Ramonell, Shunsuke Otani, Jerome C. Anyalebechi, Craig M. Coopersmith, Deena B. Chihade, Zhe Liang, Jianfeng Xie, Wenxiao Zhang
Publikováno v:
JCI Insight
TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 ti
Autor:
Craig M. Coopersmith, Yini Sun, Mandy L. Ford, Ming Xue, Jerome C. Anyalebechi, Danya Liu, Zhe Liang, Tetsuya Yumoto, He Sun
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating seps
Autor:
Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford, Deena B. Chihade, Wenxiao Zhang, Zhe Liang, Alton B. Farris, John D. Lyons, Eileen M. Burd
Publikováno v:
Shock
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer fo
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Autor:
Christian P. Larsen, Sara A. Guasch, Maylene E. Wagener, Scott M. Krummey, Ching wen Chen, Danya Liu, Mandy L. Ford
Publikováno v:
The Journal of Immunology. 197:2009-2015
The affinity of a TCR binding to peptide:MHC profoundly impacts the phenotype and function of effector and memory cell differentiation. Little is known about the effect of low-affinity priming on memory cell generation and function, which is particul
Autor:
Mandy L. Ford, Craig M. Coopersmith, Nathan J. Klingensmith, Ching-Wen Chen, Zhe Liang, Wenxiao Zhang, Yini Sun, Eileen M. Burd, Kristen N. Morrow, Katherine T. Fay
Publikováno v:
FASEB J
The microbiome is increasingly implicated in immune regulation and mortality from sepsis. Mice with identical genetic backgrounds but distinct microbiomes were obtained from different vendors and analyzed following cecal ligation and puncture (CLP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85751d6123c6877afa0adeec83fa4a5d
https://europepmc.org/articles/PMC6766641/
https://europepmc.org/articles/PMC6766641/
Autor:
Jianfeng Xie, Sonia J. Laurie, Gregory S. Martin, Craig M. Coopersmith, Wenxiao Zhang, Ching-Wen Chen, Shunsuke Otani, Mandy L. Ford, Yini Sun
Publikováno v:
JCI Insight. 4
Recent seminal studies have revealed that laboratory mice differ from adult humans with regard to the frequency, number, and distribution of memory T cells. Because our data show that memory T cells are more susceptible to sepsis-induced death than n
Autor:
Eileen M. Burd, Alton B. Farris, Zhe Liang, Mandy L. Ford, Nathan J. Klingensmith, Jack L. Arbiser, Ching-Wen Chen, Craig M. Coopersmith
Honokiol is a biphenolic isolate extracted from the bark of the magnolia tree that has been used in traditional Chinese and Japanese medicine, and has more recently been investigated for its anti-inflammatory and anti-bacterial properties. Honokiol h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f098a00ec615781395d8fc18c96441a
https://europepmc.org/articles/PMC5895534/
https://europepmc.org/articles/PMC5895534/
Autor:
Zhe Liang, Mandy L. Ford, Deena B. Chihade, Ching-Wen Chen, Nathan J. Klingensmith, Katherine T. Fay, John D. Lyons, Kimberly M. Ramonell, Craig M. Coopersmith
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202656 (2018)
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3+ Treg, and T cell apoptosis. However, the role of CD43 dur
Autor:
Zhe Liang, Deena B. Chihade, Craig M. Coopersmith, Kimberly M. Ramonell, Wenxiao Zhang, Ching-Wen Chen, Mandy L. Ford, Jianfeng Xie
Publikováno v:
J Leukoc Biol
Patients with cancer are at an increased risk of developing and dying from sepsis. We previously reported that blockade of the chemokine receptor CXCR4 resulted in decreased CD4+ T cell exhaustion and improved survival in a model of polymicrobial sep