Zobrazeno 1 - 10
of 24
pro vyhledávání: '"George Kassiotis"'
Autor:
Chrysoula Kordella, Elli Papaemmanuil, George Kassiotis, Jan Attig, Menelaos Papoutselis, George R. Young, Ioannis Kotsianidis, Anastasiya Kazachenka, George Vrachiolias, Elsa Bernard, Eleftheria Lamprianidou, Emmanuela Zoulia
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Genome Medicine
Genome Medicine
BackgroundMyelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-a
Autor:
Lydia Kalafati, Panayiotis Garantziotis, Eleftheria Lamprianidou, Ioannis Kotsianidis, Chryssoula Kordella, Athanasios Galanopoulos, Nora Viniou, Stamatia Laidou, Elsa Bernard, Ioannis Mitroulis, Anastasia Chatzidimitriou, Emmanouela Zoulia, Vassiliki Pappa, Anastasiya Kazachenka, Theodoros P. Vassilakopoulos, George Kassiotis, Anastasia Filia, Elli Papaemmanuil, Evangelia Nakou, Sotirios G. Papageorgiou
Publikováno v:
Blood Adv
CD4+ T cells orchestrate immune responses and are actively engaged in shaping tumor immunity. Signal transducer and activator of transcription (STAT) signaling controls the epigenetic tuning of CD4+ T-cell differentiation and polarization, and pertur
Publikováno v:
Cellular and Molecular Immunology
CD4+ T cells integrate well-defined signals from the T-cell receptor (TCR) (signal 1) and a host of costimulatory molecules (signal 2) to initiate clonal expansion and differentiation into diverse functional T helper (Th) subsets. However, our abilit
Autor:
Jan Attig, Urszula Eksmond, Julia Merkenschlager, Pavel Tolar, Carla R. Nowosad, George Kassiotis, George R. Young, Luca Danelli
Best known for presenting antigenic peptides to CD4+ T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce837a9a575dc464ff0f7902193a2f3
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
CD4+ T cell differentiation is influenced by a plethora of intrinsic and extrinsic factors, providing the immune system with the ability to tailor its response according to specific stimuli. Indeed, different classes of pathogens may induce a distinc
Autor:
George Kassiotis, Kim J. Hasenkrug, Mario L. Santiago, Ulf Dittmer, Bradley S. Barrett, Kathrin Gibbert, Sam X. Li, Kejun Guo
Publikováno v:
Scientific Reports
Tetherin/BST-2 is a host restriction factor that inhibits retrovirus release from infected cells in vitro by tethering nascent virions to the plasma membrane. However, contradictory data exists on whether Tetherin inhibits acute retrovirus infection
Autor:
Mickaël J.-Y. Ploquin, Andrew Filby, Julia Merkenschlager, Rakieb Andargachew, Urszula Eksmond, George Kassiotis, Georgina Thorborn, Brian D. Evavold, Marion Pepper
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate antigen reactivity. Current models attribute T cell clonal selection during the immune response to T-cell receptor
Autor:
Rebecca Pike, Andrew Filby, Urszula Eksmond, Kim J. Hasenkrug, Mickaël J.-Y. Ploquin, Inês Antunes, Rute Marques, George Kassiotis
Publikováno v:
Journal of Virology. 83:11211-11222
Recovery from infection requires concerted actions by the immune system, coordinated by CD4+ T helper cells. The importance of the CD4+ T-cell response in controlling multiple pathogens is illustrated in primary (8) or acquired CD4+ T-cell immunodefi
Autor:
Kim J. Hasenkrug, Michihiro Iwashiro, Bernard Malissen, Kagemasa Kuribayashi, George Kassiotis, Adrien Kissenpfennig, Inês Antunes, Mauro Tolaini
Publikováno v:
Immunity
Antunes, I, Tolaini, M, Kissenpfennig, A, Iwashiro, M, Kuribayashi, K, Malissen, B, Hasenkrug, K & Kassiotis, G 2008, ' Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. ', Immunity, vol. 29(5), no. 5, pp. 782-794 . https://doi.org/10.1016/j.immuni.2008.09.016
Antunes, I, Tolaini, M, Kissenpfennig, A, Iwashiro, M, Kuribayashi, K, Malissen, B, Hasenkrug, K & Kassiotis, G 2008, ' Retrovirus-specificity of regulatory T cells is neither present nor required in preventing retrovirus-induced bone marrow immune pathology. ', Immunity, vol. 29(5), no. 5, pp. 782-794 . https://doi.org/10.1016/j.immuni.2008.09.016
Chronic viral infections of the hematopoietic system are associated with bone marrow dysfunction, to which both virus-mediated and immune-mediated effects may contribute. Using unresolving noncytopathic Friend virus (FV) infection in mice, we showed
Publikováno v:
The Journal of Immunology. 177:968-975
Infection or immunization induces heterogeneous memory T cell subsets, but their origin and protective value against infection are unclear. In this study, we report the functional characterization of two memory Th subsets, defined by expression of in