Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Mandy L. Ford, Ching-Wen Chen, Kimberly M. Ramonell, Shunsuke Otani, Jerome C. Anyalebechi, Craig M. Coopersmith, Deena B. Chihade, Zhe Liang, Jianfeng Xie, Wenxiao Zhang
Publikováno v:
JCI Insight
TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 ti
Autor:
Craig M. Coopersmith, Yini Sun, Mandy L. Ford, Ming Xue, Jerome C. Anyalebechi, Danya Liu, Zhe Liang, Tetsuya Yumoto, He Sun
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating seps
Autor:
Lumelle A. Schneeweis, Steven G. Nadler, Danya Liu, Dawn K. Stetsko, Scott M. Krummey, Maylene E. Wagener, I. Raul Badell, Mandy L. Ford, Suzanne J. Suchard
Publikováno v:
The Journal of Experimental Medicine
Blockade of CD28 signals results in the up-regulation of 2B4 on primary CD8+ effectors and plays a critical role in controlling antigen-specific CD8+ T cell responses.
Mounting evidence in models of both autoimmunity and chronic viral infection
Mounting evidence in models of both autoimmunity and chronic viral infection
Autor:
Zhe Liang, Rohit Mittal, Lindsay M. Margoles, John D. Lyons, Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford
Publikováno v:
The Journal of surgical research. 195(2)
Background Cancer is known to modulate tumor-specific immune responses by establishing a microenvironment that leads to the upregulation of T-cell inhibitory receptors, resulting in the progressive loss of function and eventual death of tumor-specifi
Autor:
Rohit Mittal, Zhe Liang, Eileen M. Burd, Alton B. Farris, Elise R. Breed, Maylene E. Wagener, Mandy L. Ford, Benyam P. Yoseph, Craig M. Coopersmith
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e93523 (2014)
PLoS ONE
PLoS ONE
While much of cancer immunology research has focused on anti-tumor immunity both systemically and within the tumor microenvironment, little is known about the impact of pre-existing malignancy on pathogen-specific immune responses. Here, we sought to