Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Craig M. Coopersmith, Yini Sun, Mandy L. Ford, Ming Xue, Jerome C. Anyalebechi, Danya Liu, Zhe Liang, Tetsuya Yumoto, He Sun
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating seps
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Autor:
Christian P. Larsen, Sara A. Guasch, Maylene E. Wagener, Scott M. Krummey, Ching wen Chen, Danya Liu, Mandy L. Ford
Publikováno v:
The Journal of Immunology. 197:2009-2015
The affinity of a TCR binding to peptide:MHC profoundly impacts the phenotype and function of effector and memory cell differentiation. Little is known about the effect of low-affinity priming on memory cell generation and function, which is particul
Autor:
Mandy L. Ford, Craig M. Coopersmith, Nathan J. Klingensmith, Ching-Wen Chen, Zhe Liang, Wenxiao Zhang, Yini Sun, Eileen M. Burd, Kristen N. Morrow, Katherine T. Fay
Publikováno v:
FASEB J
The microbiome is increasingly implicated in immune regulation and mortality from sepsis. Mice with identical genetic backgrounds but distinct microbiomes were obtained from different vendors and analyzed following cecal ligation and puncture (CLP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85751d6123c6877afa0adeec83fa4a5d
https://europepmc.org/articles/PMC6766641/
https://europepmc.org/articles/PMC6766641/
Autor:
Zhe Liang, Deena B. Chihade, Craig M. Coopersmith, Kimberly M. Ramonell, Wenxiao Zhang, Ching-Wen Chen, Mandy L. Ford, Jianfeng Xie
Publikováno v:
J Leukoc Biol
Patients with cancer are at an increased risk of developing and dying from sepsis. We previously reported that blockade of the chemokine receptor CXCR4 resulted in decreased CD4+ T cell exhaustion and improved survival in a model of polymicrobial sep
Autor:
Ching-Wen, Chen, Rohit, Mittal, Nathan J, Klingensmith, Eileen M, Burd, Cox, Terhorst, Greg S, Martin, Craig M, Coopersmith, Mandy L, Ford
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(6)
Sepsis is a leading cause of death in the U.S. but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memory CD8+ T cells that h
Autor:
Mandy L. Ford, John D. Lyons, Wenxiao Zhang, Annette Hadley, Kimberly M. Ramonell, Kevin W. McConnell, Nathan J. Klingensmith, Craig M. Coopersmith, Ching-Wen Chen, Katherine T. Fay
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188882 (2017)
PLoS ONE
PLoS ONE
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4
Autor:
Lumelle A. Schneeweis, Steven G. Nadler, Danya Liu, Dawn K. Stetsko, Scott M. Krummey, Maylene E. Wagener, I. Raul Badell, Mandy L. Ford, Suzanne J. Suchard
Publikováno v:
The Journal of Experimental Medicine
Blockade of CD28 signals results in the up-regulation of 2B4 on primary CD8+ effectors and plays a critical role in controlling antigen-specific CD8+ T cell responses.
Mounting evidence in models of both autoimmunity and chronic viral infection
Mounting evidence in models of both autoimmunity and chronic viral infection
Autor:
Amelia R. Hofstetter, Aron E. Lukacher, Jarad J. Wilson, Andrew G. Brooks, Annette Hadley, Lucy C. Sullivan, Mandy L. Ford
Publikováno v:
The Journal of Immunology. 188:3071-3079
We recently identified a protective MHC class Ib-restricted CD8 T cell response to infection with mouse polyomavirus. These CD8 T cells recognize a peptide from aa 139–147 of the VP2 viral capsid protein bound to the nonpolymorphic H-2Q9 molecule,
Autor:
Pyong Woo Park, Carolyn A. Haller, Julianty Angsana, Sumona Smith, Jing Wen, Elliot L. Chaikof, Mandy L. Ford, Jiantao Xiao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:386-396
Objective— Chronic inflammation drives progressive and pathological remodeling inherent to formation of abdominal aortic aneurysm (AAA). Syndecan-1 (Sdc-1) is a cell surface heparan sulfate proteoglycan that displays the capacity to modulate inflam