Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christoph W. Grathwol"'
Autor:
Sascha Grobe, Thomas Bayer, Emil Hamnevik, Sven Koban, Uwe T. Bornscheuer, Shuke Wu, Beatrice Großjohann, Christoph W. Grathwol, Christoffel P. S. Badenhorst, Andreas Link, Henrike Brundiek
Publikováno v:
Angewandte Chemie (International Ed. in English)
We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo‐ and regioselective 7β‐hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydro
Autor:
Christoph W. Grathwol, Klaus Weisz, Yoanes Maria Vianney, Andreas Link, Qingyun Tang, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
ChemCatChem. 12:3721-3727
Methylation of free hydroxyl groups is an important modification for flavonoids. It not only greatly increases absorption and oral bioavailability of flavonoids, but also brings new biological activities. Flavonoid methylation is usually achieved by
Autor:
Qingyun Tang, Christoph W. Grathwol, Shuke Wu, Christoffel P. S. Badenhorst, Andreas Link, Aşkın S. Aslan-Üzel, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently sh