Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Sven De Marothy, Ewa Broclawik, Tomasz Borowski, Christopher J. Schofield, Per E. M. Siegbahn
The mechanism of the oxidative cyclization reaction catalyzed by clavaminic acid synthase (CAS) was studied in silico. First, a classical molecular dynamics (MD) simulation was performed to obtain a realistic structure of the CAS-Fe(IV)=O-succinate-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b24ff42afb96ef41500f70a7446db5
https://ora.ox.ac.uk/objects/uuid:16f370dc-6b11-4b33-9664-b7d65e6b37fd
https://ora.ox.ac.uk/objects/uuid:16f370dc-6b11-4b33-9664-b7d65e6b37fd
Publikováno v:
Chemistry & Biology. 16(6):580-583
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic reg
Publikováno v:
Trends in biochemical sciences. 36(1)
Pioneering work in the 1960s defined prolyl and lysyl hydroxylations as physiologically important oxygenase-catalyzed modifications in collagen biosynthesis; subsequent studies demonstrated that extracellular epidermal growth factor-like domains were
Autor:
Kirsty S. Hewitson, Adam P. Hardy, Samantha L. Holmes, Rasheduzzaman Chowdhury, Christopher J. Schofield, Michael A. McDonough, Dominic Ehrismann
Publikováno v:
The Journal of biological chemistry. 283(38)
A 2-His-1-carboxylate triad of iron binding residues is present in many non-heme iron oxygenases including the Fe(II) and 2-oxoglutarate (2OG)-dependent dioxygenases. Three variants (D201A, D201E, and D201G) of the iron binding Asp-201 residue of an
Publikováno v:
Nature chemical biology. 3(2)
The iron(II)- and 2-oxoglutarate-dependent oxygenases catalyze varied oxidative reactions. Spectroscopic analyses on the catalytic cycle of the chlorinating enzyme CytC3 reveal the presence of chloride–iron(IV)–oxo complexes, expanding the scope
Autor:
Zhihong Zhang, J. K. Robinson, Takane Hara, John N. Barlow, Janos Hajdu, Jack E. Baldwin, Peter L. Roach, Christopher J. Schofield, Philip John, I.J. Clifton, Eddie Gibson, Charles M. H. Hensgens, Abby Hassan, Andy G. Prescott, Matthew D. Lloyd
Publikováno v:
Europe PubMed Central
Autor:
Cyril Papamicaël, Michael A. McDonough, Luke A. McNeill, Biswadip Banerji, Kirsty S. Hewitson, Melanie Tilliet, Qiu-Yun Chen, Christopher J. Schofield
Publikováno v:
Journal of the American Chemical Society. 127:7680-7681
A set of four non-heme iron(II) and 2-oxoglutarate-dependent enzymes catalyze the post-translational modification of a transcription factor, hypoxia inducible factor (HIF), that mediates the hypoxic response in animals. Hydroxylation of HIF both caus
Autor:
Christopher J. Schofield, Anthony S. Wierzbicki, Matthew D. Lloyd, Mridul Mukherji, Nadia J. Kershaw
Publikováno v:
Chemistry & Biology. (5):597-605
Since it possesses a 3-methyl group, phytanic acid is degraded by a peroxisomal α-oxidation pathway, the first step of which is catalyzed by phytanoyl-CoA 2-hydroxylase (PAHX). Mutations in human PAHX cause phytanic acid accumulations leading to Adu