Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Yong J. Lee"'
Autor:
Yong Seok Park, Kalishwaralal Kalimuthu, Yong J. Lee, Ja Lok Ku, Jin Hong Kim, Xu Luo, Lin Zhang, M. Haroon A. Choudry
Publikováno v:
Journal of Cellular Physiology. 236:6666-6677
Abnormalities of the tumor vasculature result in insufficient blood supply and development of a tumor microenvironment that is characterized by low glucose concentrations, low extracellular pH, and low oxygen tensions. We previously reported that glu
Publikováno v:
British Journal of Pharmacology. 157:1189-1202
Background and purpose: Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptotic death in a variety of cancer cells without marked toxicity to most normal cells. We previously reported that wogonin, a potent anticancer agen
Publikováno v:
Journal of Cellular Biochemistry. 104:1172-1180
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL shows strong cytotoxicity to many cancer cells but minimal cytotoxicity to most normal cells. Interestingly, our recent studies have demonstrate
Publikováno v:
Biochemical Pharmacology. 75:2345-2355
The aim of this study was to investigate the effect of quercetin, a flavonoid, on the apoptotic pathway in a human prostate cell line (LNCaP). We observed that treatment of cells for 24h with quercetin-induced cell death in a dose-dependent manner. A
Autor:
Yong J. Lee, Young-Ho Kim
Publikováno v:
Journal of Cellular Biochemistry. 100:998-1009
TNF-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapy that preferentially induces apoptosis in cancer cells. However, many neoplasms are resistant to TRAIL by mechanisms that are poorly understood. Here we demonstrated that huma
TRAIL has been shown to induce apoptosis in cancer cells, but in some cases, certain cancer cells are resistant to this ligand. In this study, we explored the ability of representative HSP90 (heat shock protein 90) inhibitor NVP-AUY922 to overcome TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a04d6ec283ada7a9955e24eb741dd94
https://europepmc.org/articles/PMC4276460/
https://europepmc.org/articles/PMC4276460/
Autor:
Jedrzej Antosiewicz, Yan Zeng, Sanjay K. Srivastava, Karen L. Lew, Hui Xiao, Yong J. Lee, Dong Xiao, Simon C. Watkins, Anna Herman-Antosiewicz, Shivendra V. Singh, Donald L. Trump, Candace S. Johnson, Sunga Choi
Publikováno v:
Journal of Biological Chemistry. 280:19911-19924
We have shown previously that sulforaphane (SFN), a constituent of many edible cruciferous vegetables including broccoli, suppresses growth of prostate cancer cells in culture as well as in vivo by causing apoptosis, but the sequence of events leadin
Publikováno v:
Molecular and Cellular Biochemistry. 270:89-97
Tumor microenvironment, which is characterized by hypoxia, low-glucose concentrations, high-lactate concentrations, low-extracellular pH, can alter the therapeutic response in tumors. In this study, we investigated whether hypoxia affects TRAIL-induc
Autor:
Michelle L. Ebbs, Srikumar M. Raja, Sunil S. Metkar, Jin H. Kim, Yong J. Lee, Christopher J. Froelich, Baikun Wang
Publikováno v:
The Journal of Cell Biology
Granzyme B (GrB), acting similar to an apical caspase, efficiently activates a proteolytic cascade after intracellular delivery by perforin. Studies here were designed to learn whether the physiologic effector, GrB-serglycin, initiates apoptosis prim
Autor:
Jessup Jm, Kyung-Hwa Lee, Song Yk, Timothy R. Billiar, Kim Hr, Dai-Wu Seol, Yong J. Lee, Kim Th
Publikováno v:
Oncogene. 20:1476-1485
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL, Apo-2L) is a recently characterized member of the family of programmed cell death-inducing ligands that includes TNF-alpha and CD95L (FasL). It is well known that TRAIL binds to the