Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Monica, McGrath"'
Autor:
Stalo Karageorgi, Monica McGrath, Julie E. Buring, Peter Kraft, Immaculata De Vivo, I-Min Lee
Publikováno v:
Gynecologic Oncology. 121:54-58
Hydroxysteroid-dehydrogenase-17b (HSD17b) genes control the last step in estrogen biosynthesis. The isoenzymes HSD17b2 and HSD17b4 in the uterus preferentially catalyze the conversion of estradiol, the most potent and active form of estrogen, to estr
Publikováno v:
Gynecologic Oncology. 117:255-259
Objective Together, steroidogenic acute regulator (StAR) and the cholesterol side chain cleavage enzyme (P450scc), which is encoded by CYP11A1 , mediate the initial and rate-limiting step in steroidogenesis. Given the role of estrogens in endometrial
Autor:
Jennifer A. Doherty, Chu Chen, Sara H. Olson, Galina Lurie, Immaculata De Vivo, Jolanta Lissowska, Xiao-Ou Shu, James V. Lacey, Veronica Wendy Setiawan, Mohammad R. Akbari, Wei Zheng, Noel S. Weiss, Steven A. Narod, Giske Ursin, Susan E. Hankinson, Montserrat Garcia-Closas, Hannah P. Yang, Douglas A. Levine, Yong-Bing Xiang, Timothy R. Rebbeck, Monica McGrath, Pamela L. Horn-Ross, Angela DeMichele, Brian E. Henderson, Xiaolin Liang, Marc T. Goodman, Christopher A. Haiman, Loic Le Marchand
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 18:242-247
Common variants in CYP19A1 (the A alleles of rs749292 and rs727479) have been associated with a 10% to 20% increase in circulating estrogen levels in postmenopausal women. We hypothesized that the presence of one or both A alleles in these single nuc
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 17:983-986
Mouse double-minute 2 homologue (MDM2) is a key negative regulator of p53, a tumor suppressor gene that initiates cell cycle arrest and apoptosis in response to DNA damage and other cellular stresses. A T > G polymorphism found in the promoter region
Objective. The insulin-like growth factor (IGF) pathway plays a critical role in the growth and development of the uterus and is believed to function as a mediator of steroid hormone actions in the endometrium. The local expression of genes encoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a873edb90915969ca2eb73ee73c5b8ab
https://europepmc.org/articles/PMC3238452/
https://europepmc.org/articles/PMC3238452/
BACKGROUND: Telomeres are protective structures at the ends of linear chromosomes, regulated by a host of associated proteins. When telomeres become dysfunctional, genomic instability ensues. The vast majority of cells undergo apoptosis, although a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ebc54661368cf7b5876387eb883649
https://europepmc.org/articles/PMC2978514/
https://europepmc.org/articles/PMC2978514/
Autor:
Julie E. Buring, Chantal Guillemette, I-Min Lee, Immaculata De Vivo, Lyne Villeneuve, Monica McGrath, Johanie Lépine
Publikováno v:
Pharmacogenetics and genomics. 19(3)
Uridine diphosphate-glucuronosyltransferases (UGTs) are a family of phase II-metabolizing enzymes involved in glucuronic acid conjugation of sex steroid hormones. UGT1A1 and UGT2B7 are expressed in the uterus and involved in the conjugation and elimi
Genome-wide association studies have identified several novel risk alleles for breast cancer. We hypothesized that genetic variants that are associated with breast cancer, a hormone-related disease, would also be associated with endometrial cancer, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf16f2aabeee5a621381b0ba6c4b5b26
https://europepmc.org/articles/PMC2605169/
https://europepmc.org/articles/PMC2605169/
Autor:
Graham A. Colditz, Lori Arbeitman, Susan E. Hankinson, Immaculata De Vivo, Monica McGrath, David J. Hunter
Publikováno v:
Carcinogenesis. 25(4)
Estrogen production and metabolism play critical roles inthe development and pathogenesis of endometrial carci-noma. Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are two key enzymes in theestrogen metabolism pathway that resul